merck millipore,默克密理博,FCMAB271A6,Milli-Mark™ Anti-phospho-ATF2 (Thr69/71) Antibody, Alexa Fluor 647, clone AW65

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	FC	M	AlexaFluor®647	Monoclonal Antibody

描述
产品目录编号	FCMAB271A6
商名	Milli-Mark
描述	Milli-Mark™ Anti-phospho-ATF2 (Thr69/71) Antibody, Alexa Fluor® 647, clone AW65
Alternate Names	CREB-2 Cyclic AMP-dependent transcription factor ATF-2 cAMP-dependent transcription factor ATF-2 Activating transcription factor 2 cAMP response element-binding protein CRE-BP1 HB16 cAMP-responsive element-binding protein 2
背景信息	Activating transcription factor 2 (ATF2) is a member of the basic region leucine zipper (bZIP) family of proteins. Transcriptionally active ATF2 recognizes and binds to specific ATF/CRE motifs as homo- or heterodimers with other bZIP transcription factors of the ATF/CREB or AP-1 families. ATF2 is regulated by phosphorylation on Thr69/71. Two major kinases known to phosphorylate these sites are the two Stress Activated Protein Kinases (SAPK) Jun and p38 that are mitogen activated protein kinases (MAPKs). Phosphorylation and dimerization are required for the full transcriptional activity of ATF2. Transcriptional regulation by ATF2 has been implicated in mediating many diverse cellular processes such as growth, differentiation, immune and stress responses, inflammatory cytokine signaling, and oncogenic transformation.

产品信息
格式	AlexaFluor®647
控制	Jurkat cells
演示	Purified Mouse monoclonal IgG1 conjugated to Alexa Fluor 647 in PBS buffer with 15mg/mL BSA, Sodium azide at 0.1%.

应用
应用	This Milli-Mark Anti-phospho-ATF2 (Thr69/71) Antibody, Alexa Fluor 647, clone AW65 is validated for use in FC for the detection of phospho-ATF2 (Thr69/71).
主要应用	Flow Cytometry

生物信息
免疫原品种	KLH-conjugated, synthetic peptide corresponding to phospho-threonine at residues 69 and 71 of human ATF2
克隆	AW65
宿主	Mouse
特异性	Antibody recognizes phospho-ATF2-(Thr69/71) antigen.
同种型	IgG1
品种反应性	Human
Species Reactivity Note	Tested and passed on Human.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_001871
Entrez基因汇总	This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Additional transcript variants have been identified but their biological validity has not been determined
基因符号	CREBP1 ATF2 CREB2
修改	Phosphorylation
纯化方法	Protein G Purified
UniProt编号	P15336
UniProt汇总	Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'- GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex.

产品使用声明
质量保证	Evaluated by flow cytometry using anisomycin treated jurkat cells
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.

包装信息
数量	100 tests

merck millipore,默克密理博,FCMAB271A6,Milli-Mark™ Anti-phospho-ATF2 (Thr69/71) Antibody, Alexa Fluor 647, clone AW65

whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech