merck millipore,默克密理愽
  • merck millipore,默克密理博,FCMAB253F,Milli-Mark™Anti-Src-FITC Antibody, clone GD11

  • merck millipore,默克密理博,FCMAB253F,Milli-Mark™Anti-Src-FITC Antibody, clone GD11

    产品名称：Milli-Mark™Anti-Src-FITC Antibody, clone GD11
    产品型号：FCMAB253F
    Milli-MarkAnti-Src-FITC Antibody, clone GD11 detects level of Src & has been published & validated for use in FC.

    merck millipore,默克密理博,FCMAB253F,Milli-Mark™Anti-Src-FITC Antibody, clone GD11

  • 产品介绍
  • merck millipore,默克密理博,FCMAB253F,Milli-Mark™Anti-Src-FITC Antibody, clone GD11

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCMFITCMonoclonal Antibody
    描述
    产品目录编号 FCMAB253F
    商名
    • Milli-Mark
    描述 Milli-Mark™Anti-Src-FITC Antibody, clone GD11
    背景信息 Src is a family of proto-oncogenic tyrosine kinases originally discovered by J. Michael Bishop and Harold E. Varmus. The discovery of Src family proteins has been instrumental to the modern understanding of cancer as a disease where normally healthy cellular signalling has gone awry. Some tumor-inducing retroviruses (such as Rous sarcoma virus (RSV)), contain a gene called v-src (viral-sarcoma). It was found that the v-src gene in RSV is required for the formation of cancer. Src tyrosine kinases transmit integrin-dependent signals central to cell movement and proliferation. Hallmarks of v-src induced transformation are rounding of the cell and the formation of actin rich podosomes on the basal surface of the cell. These structures are correlated with increased invasiveness, a process thought to be essential for metastasis. v-src lacks the C-terminal inhibitory phosphorylation site, and is therefore constitutively active as opposed to normal src (c-src) which is only activated under certain circumstances where it is required (e.g. growth factor signaling). v-src is therefore an instructive example of an oncogene whereas c-src is a proto-oncogene.
    产品信息
    格式 FITC
    控制
    • A431 cells.
    演示 Purified mouse monoclonal IgG1κ conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
    应用
    应用 Milli-MarkAnti-Src-FITC Antibody, clone GD11 detects level of Src & has been published & validated for use in FC.
    主要应用
    • Flow Cytometry
    生物信息
    免疫原品种 Recombinant chicken pp60src purified from extracts of E. coli containing the plasmid plac-Src (Kuo, 2006)
    克隆 GD11
    宿主 Mouse
    特异性 Antibody recognizes Human Src.
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Tested and passed on Human. Unconjugated antibody 05-184 has shown to react to Avian, Mouse, Mink, and Rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_005408
    Entrez基因汇总 This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
    基因符号
    • pp60c-src
    • SRC
    • c-src
    • p60-Src
    • SRC1
    • c-SRC
    • ASV
    纯化方法 Protein G Purified
    UniProt编号
    • P12931
    UniProt汇总 SIZE: 536 amino acids; 59835 Da

    SUBUNIT: Interacts with DDEF1/ASAP1 via its SH3 domain. Interacts with CCPG1 (By similarity). Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2.

    PTM: Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. The phosphorylated tail interacts with the SH2 domain thereby repressing kinase activity.

    SIMILARITY: SwissProt: P12931 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
    产品使用声明
    质量保证 Evaluated by flow cytometry using A431 cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
    包装信息
    数量 100 tests

    merck millipore,默克密理博,FCMAB253F,Milli-Mark™Anti-Src-FITC Antibody, clone GD11

上一件merck millipore产品：merck millipore,默克密理博,14-716,DCAMKL2 Protein, active, 10 µg
下一件merck millipore产品：merck millipore,默克密理博,MAB4304,Anti-Stage-Specific Embryonic Antigen-4 Antibody, clone MC-813-70


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