merck millipore,默克密理愽
  • merck millipore,默克密理博,559292,InSolution™ RSK Inhibitor, SL0101 - Calbiochem

  • merck millipore,默克密理博,559292,InSolution™ RSK Inhibitor, SL0101 - Calbiochem

    产品名称：InSolution™ RSK Inhibitor, SL0101 - Calbiochem
    产品型号：559292
    The InSolution™ RSK Inhibitor, SL0101 controls the biological activity of RSK. This small molecule/inhibitor is primarily used for Cell Signaling applications.

    merck millipore,默克密理博,559292,InSolution™ RSK Inhibitor, SL0101 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,559292,InSolution™ RSK Inhibitor, SL0101 - Calbiochem

    重要规格表

    经验配方
    C₂₅H₂₄O₁₂
    描述
    概述 A cell-permeable Kaempferol (Cat. No. 420345) glycoside that targets the the N-terminal kinase domain of p90 ribosomal S6 kinase and inhibits RSK kinase activity (IC50 = 89 nM with 10 µM ATP) in a selective, reversible, and ATP-competitive (Ki = 1 µM) manner. Shown to inhibit the proliferation of MCF-7, but not the normal breast cell line MCF-10A, and specifically block PDB-induced cellular phosphorylation of RSK substrate p140, but not that of RSK or RSK upstream kinases even at concentrations as high as 100 µM. The solid form (Cat. No. 559285) is also available.
    产品目录编号 559292
    品牌系列 Calbiochem®
    参考
    参考 Smith, J.A., et al. 2007. Bioorg. Med. Chem. 15, 5018.
    Smith, J.A., et al. 2006. Bioorg. Med. Chem. 14, 6043.
    Xu, Y.M., et al. 2006. Bioorg. Med. Chem. 14, 3974.
    Maloney, D.J. and Hecht, S.M., 2005. Org. Lett. 7, 1097.
    Smith, J.A., et al. 2005. Cancer Res. 65, 1027.
    产品信息
    形式 Liquid
    配方 A 10 mM (500 µg/97 µl) solution of RSK Inhibitor, SL0101 (Cat. No. 559285) in DMSO.
    Hill配方 C₂₅H₂₄O₁₂
    化学配方 C₂₅H₂₄O₁₂
    Molar Mass 516.5
    吸湿 Hygroscopic
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    安全信息
    R相 R: 36/38

    Irritating to eyes and skin.
    储存和货运信息
    货运代码 Dry Ice Only
    毒性 Irritant
    储存 -20°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following initial thaw, aliquot and freeze (-20°C).
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,559292,InSolution™ RSK Inhibitor, SL0101 - Calbiochem

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