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merck millipore,默克密理博,FCMAB202AP,Milli-Mark™ Anti-CD61-APC Antibody, clone Y2/51
产品名称:Milli-Mark™ Anti-CD61-APC Antibody, clone Y2/51
产品型号:FCMAB202AP
Milli-Mark Anti-CD61-APC Antibody, clone Y2/51 is an antibody against CD61-APC for use in FC.
merck millipore,默克密理博,FCMAB202AP,Milli-Mark™ Anti-CD61-APC Antibody, clone Y2/51
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H FC M APC Monoclonal Antibody 描述 产品目录编号 FCMAB202AP 商名 - Milli-Mark
描述 Milli-Mark™ Anti-CD61-APC Antibody, clone Y2/51 Alternate Names - GPIIIa
- Integrin beta-3
- Platelet membrane glycoprotein IIIa
背景信息 CD61 is a selective marker of platelets and platelet precursors (Sun, 1997). CD61 is a 110 KDa single-chain protein and is the common β-subunit of the CD41/CD61 and the CD51/CD61 complexes, both of which are non-covalently associated heterodimers. The complexes require divalent cations for complex integrity and receptor functions (Sun, 1997).
The CD41/CD61 complex appears early in megakaryocyte maturation (Vinci, 1984). The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen and fibronectin (Sun, 1997) and plays a central role in platelet activation and aggregation (Nachman, 1982).
Anti-CD61, Y2/51, was included in the Fourth International Workshop and Conference on Human Leucocyte Differentiation Antigens and studies by a number of laboratories confirmed its reactivity with CD61 (von dem Borne, 1989).产品信息 格式 APC 控制 - Human Leukocytes
演示 Purified Mouse monoclonal IgG1 conjugated to APC in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2. 应用 应用 Milli-Mark Anti-CD61-APC Antibody, clone Y2/51 is an antibody against CD61-APC for use in FC. 主要应用 - Flow Cytometry
生物信息 免疫原品种 Phytohemagglutinin (PHA)-stimulated blood cells 克隆 Y2/51 宿主 Mouse 特异性 Antibody recognizes Human CD61 antigen. 品种反应性 Human Species Reactivity Note Tested and passed on Human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_000203
Entrez基因汇总 The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. 纯化方法 Protein A Purified UniProt编号 - P05106
UniProt汇总 Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. 产品使用声明 质量保证 Evaluated by flow cytometry using human leukocytes 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 tests
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