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品种反应性 主要应用 宿主 格式 抗体类型 M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB10418 描述 Anti-Puma BH3 domain Antibody Alternate Names - p53 up-regulated modulator of apoptosis
- BCL2 binding component 3
- Bcl-2 binding component 3
背景信息 PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis 产品信息 格式 Purified 控制 - Western Blot : Mouse brain lysate
演示 Purified in PBS with 0.09% NaN3. 应用 应用 Anti-Puma BH3 domain Antibody is an antibody against Puma BH3 domain for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 This antibody was developed against a synthetic peptide selected from the C-terminal region of human Puma. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 The antibody reacts with the 21 kDa Puma BH3 domain protein. 品种反应性 Mouse Species Reactivity Note Reacts with mouse. Other species have not been tested. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_055232
基因符号 - PUMA
- JFY-1
- JFY1
纯化方法 Protein G purfied UniProt编号 - Q9BXH1
UniProt汇总 FUNCTION: Essential mediator of p53-dependent and p53-independent apoptosis.
SUBUNIT STRUCTURE: Interacts with MCL1 and BCL2A1 By similarity. Interacts with BCL2 and BCL2L1/BCL-XL.
SUBCELLULAR LOCATION: Mitochondrion. Note= Localized to the mitochondria in order to induce cytochrome c release.
TISSUE SPECIFICTY: Ubiquitously expressed.
INDUCTION: By DNA damage, glucocorticoid treatment, growth factor deprivation and p53.
SEQUENCE SIMILARITIES: Belongs to the Bcl-2 family.
产品使用声明 质量保证 Western Blot Analysis: 1:250 dilution of this antibody detected Puma BH3 domain on mouse brain lysate. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store at 2-8°C for 6 months from date of receipt. For long term storage, store at -20°C 包装信息 数量 100 µg
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