merck millipore,默克密理愽
  • merck millipore,默克密理博,FCMAB195F,Milli-Mark™ Anti-CD41-FITC Antibody, clone 5B12

  • merck millipore,默克密理博,FCMAB195F,Milli-Mark™ Anti-CD41-FITC Antibody, clone 5B12

    产品名称：Milli-Mark™ Anti-CD41-FITC Antibody, clone 5B12
    产品型号：FCMAB195F
    This Milli-Mark Anti-CD41-FITC Antibody, clone 5B12 is validated for use in FC for the detection of CD41.

    merck millipore,默克密理博,FCMAB195F,Milli-Mark™ Anti-CD41-FITC Antibody, clone 5B12

  • 产品介绍
  • merck millipore,默克密理博,FCMAB195F,Milli-Mark™ Anti-CD41-FITC Antibody, clone 5B12

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCMFITCMonoclonal Antibody
    描述
    产品目录编号 FCMAB195F
    商名
    • Milli-Mark
    描述 Milli-Mark™ Anti-CD41-FITC Antibody, clone 5B12
    Alternate Names
    • GPIIb
    • Integrin alpha-IIb
    • Platelet membrane glycoprotein IIb
    • GPalpha IIb
    背景信息 CD41 is the α-subunit of the CD41/CD61 complex (GPIIb-IIIa), a calcium-dependent, non-covalently associated heterodimer. CD41 is a 135 kDa molecule, consisting of 2 peptides: a 120 kDa α chain and a 23 kDa β chain. The α chain and the β chain are linked by a single disulphide bond. The α chain contains four calcium-binding sites and is entirely extracellular, while the β-chain has extracellular, transmembrane, and cytoplasmic domains (Sun, 1997). The CD41/CD61 complex appears early in megakaryocyte maturation (Vinci, 1984). Anti-CD41, 5B12, was included in the Fifth International Workshop and Conference on Human Leukocyte Differentiation Antigens and studies by a number of laboratories confirmed its reactivity with CD41 (Honda, 1995).
    产品信息
    格式 FITC
    控制
    • TF-1 cells
    演示 Purified Mouse monoclonal IgG1 conjugated to FITC in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.
    应用
    应用 This Milli-Mark Anti-CD41-FITC Antibody, clone 5B12 is validated for use in FC for the detection of CD41.
    主要应用
    • Flow Cytometry
    生物信息
    免疫原品种 Normal human platelets
    克隆 5B12
    宿主 Mouse
    特异性 Antibody recognizes Human CD41 antigen.
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Tested and passed on Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_000410
    Entrez基因汇总 ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
    纯化方法 Protein A Purified
    UniProt编号
    • P08514
    UniProt汇总 Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
    产品使用声明
    质量保证 Evaluated by flow cytometry using TF-1 cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.
    包装信息
    数量 100 tests

    merck millipore,默克密理博,FCMAB195F,Milli-Mark™ Anti-CD41-FITC Antibody, clone 5B12

上一件merck millipore产品：merck millipore,默克密理博,MAB2078Z,Anti-Integrin α9β1 Antibody, clone Y9A2, azide free
下一件merck millipore产品：merck millipore,默克密理博,SF-1984,CTGF; Human, Cyanine 5 RNA Detection Probe,SmartFlare


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