merck millipore,默克密理博,FCMAB143F,Milli-Mark Anti-RPA2 p34 -FITC Antibody, clone RPA20 1-46

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	FC	M	FITC	Monoclonal Antibody

描述
产品目录编号	FCMAB143F
商名	Milli-Mark
描述	Milli-Mark Anti-RPA2 p34 -FITC Antibody, clone RPA20 1-46
Alternate Names	RF-A protein 2 <br />RP-A p32 <br />RP-A p34 <br />Replication factor A protein 2 <br />replication protein A2 (32kD) <br />replication protein A2, 32kDa <br />Replication protein A 32kDa subunit <br />RF-A, replication factor-A protein 2 <br />p32 <br />p34 <br />RPA2 <br />REPA2 <br />RPA32.
背景信息	RPA is a heterotrimeric protein complex that binds specifically to single-stranded DNA (ssDNA). It is composed of three subunits, RPA1 (70 kDa), RPA2 (32 kDa), and RPA3 (14 kDa), and plays multiple roles in DNA metabolism. RPA is required for DNA replication initiation, as well as replication elongation. At the onset of DNA replication, RPA is loaded onto chromatin after the binding of Cdc45 to origins. RPA is needed for subsequent loading of DNA polymerase and other replication proteins to initiate DNA replication. After DNA replication begins, RPA moves with replication forks, stabilizing ssDNA and assisting in DNA synthesis. In addition to its replication function, RPA is also known to play essential roles in damage repair and recombination.The 32 kDa subunit, is phosphorylated by the cdc2 family of kinases when cells enter S-phase and in response to DNA damage by ATM, ATR, and DNA-PK. Alternate names for RPA32 include replication protein A 32 kDa subunit, RP-A, RF-A, replication factor-A protein 2, p32, p34, RPA2, REPA2, and RPA32.

产品信息
格式	FITC
控制	HeLa cells
演示	Purified mouse monoclonal IgG1κ conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.

应用
应用	This Milli-Mark Anti-RPA2 p34 -FITC Antibody, clone RPA20 1-46 is validated for use in FC for the detection of RPA2 p34.
主要应用	Flow Cytometry

生物信息
免疫原品种	His-tagged recombinant protein corresponding to human RPA2
表位	Unknown
克隆	RPA20, 1-46
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	Antibody recognizes RPA2
同种型	IgG1κ
品种反应性	Human
Species Reactivity Note	Tested and passed on Human. Unconjugated antibody part number 04-1481 known to react with Human and Mouse.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_002937
基因符号	RPA34 RPA2 REPA2 RPA32
纯化方法	Protein G purfied
UniProt编号	P15927
UniProt汇总	FUNCTION: Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. SUBUNIT STRUCTURE: Heterotrimer of 70, 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Binds to SERTAD3/RBT1. Interacts with TIPIN. SUBCELLULAR LOCATION: Nucleus. Note: Also present in PML nuclear bodies. Redistributes to discrete nuclear foci upon DNA damage. PTM: Phosphorylated in a cell-cycle-dependent manner (from the S phase until mitosis). Phosphorylated by ATR upon DNA damage, which promotes its translocation to nuclear foci. Can be phosphorylated in vitro by PRKDC/DNA-PK in the presence of Ku and DNA, and by CDC2.

产品使用声明
质量保证	Evaluated by flow cytometry using HeLa cells.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

包装信息
数量	100 tests

merck millipore,默克密理博,FCMAB143F,Milli-Mark Anti-RPA2 p34 -FITC Antibody, clone RPA20 1-46

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