merck millipore,默克密理愽
  • merck millipore,默克密理博,FCMAB126F,Milli-Mark Anti-CD45RA-FITC Antibody, clone MEM 56

  • merck millipore,默克密理博,FCMAB126F,Milli-Mark Anti-CD45RA-FITC Antibody, clone MEM 56

    产品名称：Milli-Mark Anti-CD45RA-FITC Antibody, clone MEM 56
    产品型号：FCMAB126F
    Milli-Mark Anti-CD45RA-FITC Antibody, clone MEM 56 is an antibody against CD45RA for use in FC.

    merck millipore,默克密理博,FCMAB126F,Milli-Mark Anti-CD45RA-FITC Antibody, clone MEM 56

  • 产品介绍
  • merck millipore,默克密理博,FCMAB126F,Milli-Mark Anti-CD45RA-FITC Antibody, clone MEM 56

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HFCMFITCMonoclonal Antibody
    描述
    产品目录编号 FCMAB126F
    商名
    • Milli-Mark
    描述 Milli-Mark Anti-CD45RA-FITC Antibody, clone MEM 56
    Alternate Names
    • CD45 antigen <br />Leukocyte common antigen precursor <br />SCID due to PTPRC deficiency <br />T200 glycoprotein <br />T200 leukocyte common antigen <br />Human homolog of severe combined immunodeficiency due to PTPRC deficiency <br />Leukocyte-common antigen <br />Protein tyrosine phosphatase, receptor type, C <br />Protein tyrosine phosphatase, receptor type, c polypeptide
    背景信息 CD45 is a receptor-tyrosine phosphatase required for antigen-induced signaling in T-cells and B-cells; its substrates are unknown. Interestingly, it associates with several Src-family tyrosine kinases, which are inhibited by tyrosine phosphorylation in their c-termini, suggesting a mechanism for signaling by CD45.
    产品信息
    格式 FITC
    控制
    • Jurkat cells.
    演示 Purified mouse monoclonal IgG2b conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
    应用
    应用 Milli-Mark Anti-CD45RA-FITC Antibody, clone MEM 56 is an antibody against CD45RA for use in FC.
    主要应用
    • Flow Cytometry
    应用说明
    Working Solution Cells / test Total Reaction Volume
    5 μl 5 x 105 Cells / 95 μl PBS 100 μl
    10 μl 1 x 106 Cells / 90 μl PBS 100 μl
    生物信息
    免疫原品种 Human thymocytes and T lymphocytes.
    表位 Unknown
    克隆 MEM56
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes the 220 kDa molecular weight component of the leucocyte common antigen complex expressed on some CD4+ T lymphocytes, B lymphocytes and CD8+ lymphocytes.
    同种型 IgG2bκ
    品种反应性 MouseHuman
    Species Reactivity Note Tested and passed on Human. Predicted to react with Rat and Mouse based on 100% sequence homology.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_002829.2
    Entrez基因汇总 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
    基因符号
    • EC 3.1.3.48
    • PTPRC
    • L-CA
    • LCA
    • CD45
    • LY5
    • T200
    • Glycoprotein
    • B220
    • GP180
    纯化方法 Protein A purfied
    UniProt编号
    • P08575
    UniProt汇总 FUNCTION: SwissProt: P08575 # Required for T-cell activation through the antigen receptor. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits an dephosphorylates SKAP1 and FYN.

    SIZE: 1304 amino acids; 147254 Da

    SUBUNIT: Binds GANAB and PRKCSH (By similarity). Interacts with SKAP1.

    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

    DOMAIN: SwissProt: P08575 The first PTPase domain interacts with SKAP1.

    PTM: Heavily N- and O-glycosylated.

    DISEASE: SwissProt: P08575 # Defects in PTPRC are a cause of autosomal recessive severe combined immunodeficiency T-cell-negative/B-cell- positive/NK cell-positive (T(-)/B(+)/NK(+) SCID) [MIM:608971]. SCID refers to a genetically and clinically group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients with SCID present in infancy with recurrent, persistent infections by opportunistic organisms, including Candida albicans, Pneumocystis carinii, and cytomegalovirus, among many others. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T- cell development. & Genetic variations in PTPRC are involved in multiple sclerosis susceptibility (MS) [MIM:126200]. MS is a neurodegenerative disorder characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in third or fourth decade with intermittent progression over an extended period. The cause is still uncertain.

    SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily. & Contains 2 fibronectin type-III domains. & Contains 2 tyrosine-protein phosphatase domains.
    产品使用声明
    质量保证 Evaluated by flow cytometery using Jurkat cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Storage and Handling section needs to say: Maintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.
    包装信息
    数量 100 tests

    merck millipore,默克密理博,FCMAB126F,Milli-Mark Anti-CD45RA-FITC Antibody, clone MEM 56

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