merck millipore,默克密理愽
  • merck millipore,默克密理博,251406,D-Amino Acid Oxidase Inhibitor III, AS057278 - CAS 402-61-9 - Calbiochem

  • merck millipore,默克密理博,251406,D-Amino Acid Oxidase Inhibitor III, AS057278 - CAS 402-61-9 - Calbiochem

    产品名称：D-Amino Acid Oxidase Inhibitor III, AS057278 - CAS 402-61-9 - Calbiochem
    产品型号：251406


    merck millipore,默克密理博,251406,D-Amino Acid Oxidase Inhibitor III, AS057278 - CAS 402-61-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,251406,D-Amino Acid Oxidase Inhibitor III, AS057278 - CAS 402-61-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₅H₆N₂O₂402-61-9
    描述
    概述 A cell-permeable pyrazolocarboxylic acid that acts as a selective D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) inhibitor (IC50 = 910 nM against human DAO; [D-ser] = 10 mM) and effectively protects DAO overexpressing cultures from oxidative stress-induced cell death upon D-Ser (50 mM) exposure (ED50 ≤3.95 µM), while exhibiting little affinity toward NMDAR glycine binding site or inhibitory activity against D-aspartate oxidase (DDO/DSOX). Reported to be orally available and blood-brain barrier-permeant in rats and effectively prevent PCP (phencyclidine) from suppressing PPI (prepulse inhibition) response in mice (single 80 mg/kg or 56X 20 mg/kg/12 h b.i.d. oral dosages) in vivo.
    产品目录编号 251406
    品牌系列 Calbiochem®
    同义词 5-methyl-1H-pyrazole-3-carboxylic acid, DAAO Inhibitor III
    参考
    参考 Smith, S., et al. 2010. Open Med. Chem. J. 27, 3.
    Williams, M. 2009. Biochem. Pharmacol. 78, 1360.
    Adage, T., et al. 2008. Eur. Neuropsychopharmacol. 18, 200.
    产品信息
    CAS号 402-61-9
    形式 White solid
    Hill配方 C₅H₆N₂O₂
    化学配方 C₅H₆N₂O₂
    Molar Mass 126.11
    可逆 Y
    结构配方图像
    生物信息
    主靶 DAAO
    主靶IC50 910 nM
    纯度 ≥99% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,251406,D-Amino Acid Oxidase Inhibitor III, AS057278 - CAS 402-61-9 - Calbiochem

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