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品种反应性 主要应用 宿主 格式 抗体类型 R, Av, H, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 06-157 Replaces 04-577; 04-1039 品牌系列 Upstate
商名 - Upstate
描述 Anti-RasGAP Antibody 产品信息 格式 Purified 演示 200 μg of protein-A purified IgG. Lyophilized from 200 μl of 0.1 M Tris-HCl, 0.15 M NaCl, and 0.05% Na Azide. 应用 应用 Anti-RasGAP Antibody is an antibody against RasGAP for use in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Trp E fusion corresponding to residues 171-448 of human RasGAP 宿主 Rabbit 特异性 GAP 同种型 IgG 品种反应性 RatAvianHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_022650
Entrez基因汇总 The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. 基因符号 - DKFZp434N071
- RASA1
- CMAVM
- CM-AVM
- RASA
- PKWS
- GAP
- p120GAP
- RASGAP
- RasGAP
纯化方法 Protein A chromatography UniProt编号 - P20936
UniProt汇总 FUNCTION: SwissProt: P20936 # Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21.
SIZE: 1047 amino acids; 116403 Da
SUBUNIT: Interacts with SQTSM1.
SUBCELLULAR LOCATION: Cytoplasm.
PTM: The N-terminus is blocked.
DISEASE: SwissProt: P20936 # Mutations in the SH2 domain of RASA seem to be oncogenic and cause basal cell carcinomas. & Defects in RASA1 are the cause of capillary malformation- arteriovenous malformation (CMAVM) [MIM:608354]. CMAVM is a disorder characterized by atypical capillary malformations that are multiple, small, round to oval in shape and pinkish red in color. These capillary malformations are associated with either arteriovenous malformation, arteriovenous fistula, or Parkes Weber syndrome. & Defects in RASA1 are a cause of Parkes Weber syndrome (PKWS) [MIM:608355]. PKWS is a disorder characterized by a cutaneous flush with underlying multiple micro-arteriovenous fistulas, in association with soft tissue and skeletal hypertrophy of the affected limb.
SIMILARITY: SwissProt: P20936 ## Contains 1 C2 domain. & Contains 1 PH domain. & Contains 1 Ras-GAP domain. & Contains 2 SH2 domains. & Contains 1 SH3 domain.产品使用声明 质量保证 Western Immunoblot Analysis: This antibody, at 0.5 and 2.0 μg/ml, recognized the 120 kDa GAP protein in a RIPA lysate of human Raji lymphocyte cells, lysates of rat L6 myoblasts and mouse Wehi leukemia cells.
Immunoprecipitation: 5 μg of this antibody immunoprecipitated the 120kDa GAP protein from a RIPA lysate of human Raji lymphocyte cells.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Lyophilized: 2 years at -20°C; Rehydrated: 6 months at -20°C Rehydrate in 200 μl of water. 包装信息 数量 200 µg
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