merck millipore,默克密理愽
  • merck millipore,默克密理博,FCCH100139,FlowCellect™ T Cell MitoDamage Kit

  • merck millipore,默克密理博,FCCH100139,FlowCellect™ T Cell MitoDamage Kit

    产品名称：FlowCellect™ T Cell MitoDamage Kit
    产品型号：FCCH100139
    The FlowCellect T cell MitoDamage Kit allows for the detection of T-lymphocytes & T-lymphocyte subsets in peripheral blood mononuclear cell samples & provides information on the mitochondrial membrane More>>

    merck millipore,默克密理博,FCCH100139,FlowCellect™ T Cell MitoDamage Kit

  • 产品介绍
  • merck millipore,默克密理博,FCCH100139,FlowCellect™ T Cell MitoDamage Kit

    描述
    产品目录编号 FCCH100139
    商名
    • FlowCellect
    描述 FlowCellect™ T Cell MitoDamage Kit
    概述 The FlowCellect T cell MitoDamage Kit allows for the detection of T-lymphocytes and T-lymphocyte subsets in peripheral blood mononuclear cell samples and simultaneously provides information on the mitochondrial membrane potential status in a simple easy to use assay utilizing flow cytometry. The kit allows the determination of % of T cells and the subset of apoptotic T cells which have impaired mitochondrial membrane potential. Multiparametric evaluation of T Cell subpopulations along with mitochondrial membrane potential changes is of great utility in studying impact of compounds on immune cell subpopulations in drug screening studies; it can provide an understanding of the mechanistic machinery of immune cell apoptosis; provide insights into mechanism of disease and immune dysfunction and can also be of great value in quality control of immune cell sub-populations. This kit will discriminate multiple populations 1) CD4 T Helper cells and % of these cells which show intact mitochondrial membrane potential, 2) % of CD4 T Helper cells with dissipated mitochondrial membrane potential, 3) CD8 cytotoxic T Cells and the % of these cells that show intact mitochondrial membrane potential change, 4) CD8 Cytotoxic T cells and % of these cells that demonstrate dissipated membrane potential. The kit will provide a complete picture of T cell mitochondrial perturbation status and its response for inducer treatment conditions or diseases. The entire assay can be performed in 30 min in a simple no wash manner without loss of apoptotic cells when using PBMC’s.
    Alternate Names
    • Flow Cellect
    背景信息 Apoptosis plays a critical role in immune cell development, regulation and functioning of the immune system and is also a contributor to the pathology of many human diseases and disorders of immune function. Mitochondria and mitochondrial function are highly sensitive indicators of cell health and stress because of their critical role in maintaining crucial cellular energy balance, regulation of cell death processes such as apoptosis and as a primary site for production of free radicals and oxidative stress. Mitochondrial membrane potential (MMP) changes have been established to be universal and important in intrinsic pathways of immune system cell death as well as extrinsic pathways such as FAS mediated pathway of death. In addition, mitochondrial potential changes have been found to be important in granzyme B mediated cytotoxic killing pathways and caspase independent cell death in immune cell subpopulations.
    产品信息
    部件
    • 3. MitoSense Red Dye (Part No. 4300-0315) One vial containing 200µL of MitoSense Red Dye.
    • 1. CD8-FITC/CD4-PE/CD3-PECy5 (Part No.4700-1355) One vial containing 1000 µL of cocktail.
    • 2. 1X Assay Buffer BA: (Part No. 4700-1360) One vial containing 50 mL.
    检测方法 Fluorescent
    应用
    应用 The FlowCellect T cell MitoDamage Kit allows for the detection of T-lymphocytes & T-lymphocyte subsets in peripheral blood mononuclear cell samples & provides information on the mitochondrial membrane potential status.
    主要应用
    • Flow Cytometry
    生物信息
    宿主 Mouse
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    产品使用声明
    质量保证 Lot to lot in-process testing on all kit components
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 4-8°C for antibodies and buffers
    包装信息
    数量 100 Tests / Kit

    merck millipore,默克密理博,FCCH100139,FlowCellect™ T Cell MitoDamage Kit

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