merck millipore,默克密理愽
  • merck millipore,默克密理博,EGLP-35K,Glucagon Like Peptide-1 (Active) ELISA

  • merck millipore,默克密理博,EGLP-35K,Glucagon Like Peptide-1 (Active) ELISA

    产品名称：Glucagon Like Peptide-1 (Active) ELISA
    产品型号：EGLP-35K
    This Glucagon Like Peptide-1 (Active) ELISA is used to measure & quantify Glucagon Like Peptide-1 levels in Metabolism & Endocrine research.

    merck millipore,默克密理博,EGLP-35K,Glucagon Like Peptide-1 (Active) ELISA

  • 产品介绍
  • merck millipore,默克密理博,EGLP-35K,Glucagon Like Peptide-1 (Active) ELISA

    重要规格表

    可用的分析物 品种反应性 主要应用 检测方法
    Glucagon Like Peptide-1R, H, MELISAFluorescent
    描述
    产品目录编号 EGLP-35K
    描述 Glucagon Like Peptide-1 (Active) ELISA
    背景信息 GLP-1 is secreted from gut endocrine cells in response to nutrient ingestion and plays multiple roles in metabolic homeostasis.
    产品信息
    检测方法 Fluorescent
    精度（%）
    • Intra-assay: 7.4 ± 1.1
    • Inter-assay: 8 ± 4.8
    应用
    应用 This Glucagon Like Peptide-1 (Active) ELISA is used to measure & quantify Glucagon Like Peptide-1 levels in Metabolism & Endocrine research.
    主要应用
    • ELISA
    应用说明 Overnight incubation at 4°C, followed by 2 hours 30 minutes at room temperature Sample volume 100 μl serum, plasma or tissue culture medium
    生物信息
    品种反应性 RatHumanMouse
    可用的分析物
    • Glucagon Like Peptide-1
    交叉反应性 GLP-1 is conserved in almost all mammals. This kit may be used to mearure in such species (e.g. rat, mouse, primates, etc.)
    Entrez基因编号
    • NM_002054.2
    Entrez基因汇总 The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.
    基因符号
    • glucagon
    • GCG
    • GRPP
    • GLP1
    • GLP2
    UniProt编号
    • P01275
    UniProt汇总 FUNCTION: SwissProt: P01275 # Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.
    SIZE: 180 amino acids; 20909 Da
    SUBCELLULAR LOCATION: Secreted.
    TISSUE SPECIFICITY: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain.
    PTM: Proglucagon is post-translationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
    SIMILARITY: SwissProt: P01275 ## Belongs to the glucagon family.
    MISCELLANEOUS: In the glucagon antagonist, His-53 and Phe-58 are missing. This antagonist has been successfully utilized to reduce glucose concentration in vivo.
    准确度
    • 86.9 ± 5.2%
    理化信息
    标准曲线范围
    • 2–100 pM
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 96-well plate

    merck millipore,默克密理博,EGLP-35K,Glucagon Like Peptide-1 (Active) ELISA

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