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merck millipore,默克密理博,04-046,Anti-SUZ12 Antibody, clone 3C1.2
产品名称：Anti-SUZ12 Antibody, clone 3C1.2
产品型号：04-046
Anti-SUZ12 Antibody, clone 3C1.2 is a high quality Mouse Monoclonal Antibody for the detection of SUZ12 & has been validated in WB.
merck millipore,默克密理博,04-046,Anti-SUZ12 Antibody, clone 3C1.2
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 04-046 品牌系列 Upstate
商名 - Upstate
描述 Anti-SUZ12 Antibody, clone 3C1.2 背景信息 SUZ12 is a polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Component of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3. 产品信息 格式 Purified 控制 - HeLa cell lysate
演示 100 μg of Protein A purified mouse monoclonal IgG1κ in 100 μL of 1X PBS, pH 7, 0.1% Azide. 应用 应用 Anti-SUZ12 Antibody, clone 3C1.2 is a high quality Mouse Monoclonal Antibody for the detection of SUZ12 & has been validated in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Full length, recombinant human SUZ12. 克隆 clone 3C1.2 宿主 Mouse 特异性 SUZ12 同种型 IgG1κ 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_015355.1
Entrez基因汇总 This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. The specific function of this gene has not yet been determined. 基因符号 - JJAZ1
- SUZ12
- KIAA0160
- CHET9
纯化方法 Protein A purfied UniProt编号 - Q15022
UniProt汇总 FUNCTION: SwissProt: Q15022 # Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Component of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3.
SIZE: 739 amino acids; 83055 Da
SUBUNIT: Component of the PRC2 complex, composed of EED, EZH2, SUZ12/JJAZ1, RBBP4 and RBBP7. This complex is distinct from the PRC1 complex, which contains many other PcG proteins like BMI1, CBX4, CBX8, PHC2, PHC3, SCMH1, RING1 and RNF2.
SUBCELLULAR LOCATION: Nucleus (Probable).
DISEASE: SwissProt: Q15022 # A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with JAZF1. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer.
SIMILARITY: SwissProt: Q15022 ## Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family. & Contains 1 C2H2-type zinc finger.产品使用声明 质量保证 Routinely evaluated by immunoblot. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment. 包装信息 数量 100 µg
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