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merck millipore,默克密理博,528108,PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem
产品名称：PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem
产品型号：528108
The PI 3-Kγ Inhibitor II, also referenced under CAS 648449-76-7, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation ap More>>
merck millipore,默克密理博,528108,PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₁H₅F₂NO₄S 648449-76-7 描述 概述 A cell-permeable thiazolidinedione compound that acts as a potent and ATP-competitive inhibitor of PI 3-Kγ (Ki = 180 nM; IC50 = 250 nM). Exhibits great selectivity over PI 3-Kα (IC50 = 4.5 µM), PI 3-Kβ and δ (IC50 > 20 µM), and shows little effect towards a large panel of receptors, unrelated enzymes, ion channels, and 38 commonly studied kinases. Shown to block MCP-1-mediated monocyte chemotaxis in vitro and exhibit better in vivo efficacy than LY294002 (Cat. No. 440202 and 440204) in blocking RANTES- or thioglycollate-induced peritoneal neutrophil recruitment by oral administration in a murine peritonitis model. 产品目录编号 528108 品牌系列 Calbiochem®
同义词 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, PI 3-K Inhibitor II 参考 参考 Bilancio, A., et al. 2006. Blood 107, 642.
Camps, M., et al. 2005. Nat. Med. 11, 936.产品信息 CAS号 648449-76-7 具有ATP竞争性 Y 形式 Off-white solid Hill配方 C₁₁H₅F₂NO₄S 化学配方 C₁₁H₅F₂NO₄S Molar Mass 285.2 可逆 N 结构配方图像 生物信息 主靶 PI 3-Kγ 主靶IC50 250 nM against PI 3-Kγ 主靶Ki 180 nM 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Irritant
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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