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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, FC, WB M Purified Monoclonal Antibody 描述 产品目录编号 CBL553 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-CD63 Antibody, clone RFAC4 产品信息 格式 Purified 演示 The monoclonal is presented at a concentration of 100μg/1ml in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application. 应用 应用 Anti-CD63 Antibody, clone RFAC4 is an antibody against CD63 for use in FC, IP, WB, IH, IH(P). 主要应用 - Immunohistochemistry
- Flow Cytometry
- Western Blotting
应用说明 Flow cytometric studies of CD63 expression
Immunoprecipitation
Western blotting of CD63 antigen from solubilized platelet proteins
Suitable for formalin fixed paraffin wax embedded tissue sections. HIER and proteolytic pretreatment may not be necessary. Users should confirm specificity and pretreatment for their particular application.
Optimal working dilutions must be determined by the end user.生物信息 克隆 RFAC4 宿主 Mouse 特异性 This antibody reacts with a 53 kDa protein which form a part of the family of tetraspan moieties. The antigen was originally designated as a lysosomal membrane protein characterized as an activation dependent platelet surface antigen. In fact the CD63 antigen has a diverse distribution on the surface and in the cytoplasm of many cell types including lymphoid, myeloid, endothelial cells and melanoma. 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_001780.4
- NM_001040034.1
Entrez基因汇总 The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. The use of alternate polyadenylation sites has been found for this gene. Alternative splicing results in multiple transcript variants encoding different proteins. 基因符号 - Lamp-3
- CD63
- TSPAN30
- ME491
- Tetraspanin-30
- granulophysin
- LAMP-3
- tetraspanin-30
- Granulophysin
- MLA1
- OMA81H
UniProt编号 - P08962
UniProt汇总 FUNCTION: SwissProt: P08962 # This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation.
SIZE: 238 amino acids; 25637 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Note=Also found in Weibel- Palade bodies of endothelial cells.
TISSUE SPECIFICITY: Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.
SIMILARITY: SwissProt: P08962 ## Belongs to the tetraspanin (TM4SF) family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,495621,Olomoucine II - CAS 500735-47-7 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,511071,PAF Receptor Antagonist, ABT-491 - CAS 189689-94-9 - Calbiochem
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