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merck millipore,默克密理博,511071,PAF Receptor Antagonist, ABT-491 - CAS 189689-94-9 - Calbiochem
产品名称：PAF Receptor Antagonist, ABT-491 - CAS 189689-94-9 - Calbiochem
产品型号：511071
The PAF Receptor Antagonist, ABT-491, also referenced under CAS 189689-94-9, controls the biological activity of PAF Receptor. This small molecule/inhibitor is primarily used for Membrane applications More>>
merck millipore,默克密理博,511071,PAF Receptor Antagonist, ABT-491 - CAS 189689-94-9 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₈H₂₂FN₅O₂ • HCl 189689-94-9 描述 概述 An orally available ethynylindole compound that potently inhibits PAF (platelet-activating factor) binding to its receptor in a competitive manner in equilibrium binding studies (Ki = 0.6 or 3.8 nM, respectively, using intact human platelets or isolated rabbit platelet membrane; [PAF] = 0.6 nM), while a non-competitive inhibition is observed if the membrane-bound receptors are pre-incubated with the antagonist prior to the addition of PAF, presumably due to a slower antagonist dissociation rate. Shown to effectively antagonize PAF-induced platelet and neutrophil responses at submicromolar concentrations in vitro and exhibit in vivo efficacy in alleviating PAF-mediated inflammatory and pathological processes in various animals, including guinea pigs, mice, and rats, via either i.v. or p.o.. Reported to display high specificity toward PAF receptor as evaluated in binding assays employing a wide variety of receptors and ion channels. 产品目录编号 511071 品牌系列 Calbiochem®
同义词 1-(N,N-Dimethylcarbamoyl)-4-ethynyl-3-(3-fluoro-4-((1H-2-methylimidazo[4,5-c]pyridin-1-yl)methyl)benzoyl)-indole, HCl 参考 参考 Curtin, M.L., et al. 1998. J. Med. Chem. 41, 74.
Albert, D.H., et al. 1998. J. Pharmacol. Exp. Ther. 284, 83.
Albert, D.H., et al. 1997. Eur. J. Pharmacol. 325, 69.产品信息 CAS号 189689-94-9 形式 Off-white solid Hill配方 C₂₈H₂₂FN₅O₂ • HCl 化学配方 C₂₈H₂₂FN₅O₂ • HCl Molar Mass 516. 吸湿 Hygroscopic
结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 H₂O 安全信息 S相 S: 22-24/25
Do not breathe dust.
Avoid contact with skin and eyes.储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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