merck millipore,默克密理愽
  • merck millipore,默克密理博,CBL407F,Anti-PCNA Antibody, clone PC10, FITC conjugated

  • merck millipore,默克密理博,CBL407F,Anti-PCNA Antibody, clone PC10, FITC conjugated

    产品名称：Anti-PCNA Antibody, clone PC10, FITC conjugated
    产品型号：CBL407F
    Use Anti-PCNA Antibody, clone PC10, FITC conjugated (mouse monoclonal antibody) validated in FC to detect PCNA also known as Proliferating Cell Nuclear Antigen, DNA Polymerase delta Processivity Facto More>>

    merck millipore,默克密理博,CBL407F,Anti-PCNA Antibody, clone PC10, FITC conjugated

  • 产品介绍
  • merck millipore,默克密理博,CBL407F,Anti-PCNA Antibody, clone PC10, FITC conjugated

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Vrt, InvFCMFITCMonoclonal Antibody
    描述
    产品目录编号 CBL407F
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-PCNA Antibody, clone PC10, FITC conjugated
    Alternate Names
    • DNA Polymerase delta Processivity Factor
    • Proliferating Cell Nuclear Antigen
    背景信息 Proliferating cell nuclear antigen (PCNA) is a 36 kDa molecule that is highly conserved between species. PCNA was first identified as the antigen for a subpopulation of autoantibodies in patients with systemic lupus erythematosus (Miyachi, 1978; Takasaki, 1984; Ogata, 1987). It has since been determined that PCNA serves as a co-factor for DNA polymerase delta in S-phase as well as during DNA synthesis associated with mechanisms involved in DNA damage repair (Tan, 1987; Bravo, 1987). The temporal specificity of PCNA expression makes it an ideal marker for cell proliferation. PCNA begins to accumulate during the G1 phase of the cell cycle, is most abundant during the S phase, and declines during the G2/M phase (Kurki, 1988). Since the half-life of PCNA exceeds 20 hours, it may be possible to detect the protein in non-cycling cells.
    产品信息
    格式 FITC
    控制
    • POSITIVE CONTROL: Tonsil or reactive lymph node.
    演示 The conjugate is supplied as a 100 test/1 mL vial in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. For flow cytometry we recommend using 10μL of conjugate per test.
    应用
    应用 Use Anti-PCNA Antibody, clone PC10, FITC conjugated (mouse monoclonal antibody) validated in FC to detect PCNA also known as Proliferating Cell Nuclear Antigen, DNA Polymerase delta Processivity Factor.
    主要应用
    • Flow Cytometry
    应用说明 Immunostaining of malignant tumours with low and high proliferation on paraffin wax embedded sections

    Study of cell proliferation with PHA stimulated peripheral blood lymphocytes and various neoplasms

    Optimal working dilutions must be determined by the end user.
    生物信息
    克隆 PC10
    宿主 Mouse
    特异性 This monoclonal reacts with a nuclear antigen that is expressed by proliferating cells in all phases of the active cell cycle from all vertebrate species and insects.
    同种型 IgG2a
    品种反应性 VertebratesInvertebrates
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_182649.1
    • NM_002592.2
    Entrez基因汇总 The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.
    基因符号
    • MGC8367
    • PCNA
    • Cyclin
    • cyclin
    UniProt编号
    • P12004
    UniProt汇总 FUNCTION: SwissProt: P12004 # This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
    SIZE: 261 amino acids; 28769 Da
    SUBUNIT: Homotrimer. Interacts with KCTD10 (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with POLH, POLK, DNMT1, ERCC5/XPG, FEN1, CDC6, APEX2 and POLDIP2. Interacts with EXO1 and SHPRH.
    SUBCELLULAR LOCATION: Nucleus.
    PTM: Upon methyl methanesulfonate-induced DNA damage, mono- ubiquitinated by the UBE2B-RAD18 complex on Lys-164. This induces non-canonical poly-ubiquitination on Lys-164 through 'Lys-63' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligase SHPRH, whih is required for DNA repair.
    DISEASE:SwissProt: P12004 # Antibodies are present in sera from patients with systemic lupus erythematosus.
    SIMILARITY: SwissProt: P12004 ## Belongs to the PCNA family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store at +4°C protected from light. DO NOT FREEZE. For long term use and storage aliquot conjugate into small volumes and store at +4°C.
    包装信息
    数量 100 assays

    merck millipore,默克密理博,CBL407F,Anti-PCNA Antibody, clone PC10, FITC conjugated

上一件merck millipore产品：merck millipore,默克密理博,539470,Proteinase K Inhibitor - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,70840,pTriEx™-1.1 DNA - Novagen


相关产品

merck millipore,默克密理博,GF53,Anti-Tissue Plasminogen Activator (Ab-1) Mouse mAb (GMA-043) merck millipore,默克密理博,GF53,Anti-Tissue Plasminogen Activator (Ab-1) Mouse mAb (GMA-043)

merck millipore,默克密理博,567703,Spermine NONOate - CAS 136587-13-8 - Calbiochem merck millipore,默克密理博,567703,Spermine NONOate - CAS 136587-13-8 - Calbiochem

merck millipore,默克密理博,CBL412X,Anti-Tubulin β-III Antibody, clone TU-20, Alexa Fluor488 Conjugated merck millipore,默克密理博,CBL412X,Anti-Tubulin β-III Antibody, clone TU-20, Alexa Fluor488 Conjugated

merck millipore,默克密理博,04-399,Anti-PI3 Kinase Antibody, p110α rabbit monoclonal merck millipore,默克密理博,04-399,Anti-PI3 Kinase Antibody, p110α rabbit monoclonal

merck millipore,默克密理博,539470,Proteinase K Inhibitor - Calbiochem merck millipore,默克密理博,539470,Proteinase K Inhibitor - Calbiochem

merck millipore,默克密理博,70840,pTriEx™-1.1 DNA - Novagen merck millipore,默克密理博,70840,pTriEx™-1.1 DNA - Novagen

merck millipore,默克密理博,SF-426,miR-143-3p; Human, Cyanine 3, RNA Detection Probe,SmartFlare merck millipore,默克密理博,SF-426,miR-143-3p; Human, Cyanine 3, RNA Detection Probe,SmartFlare

merck millipore,默克密理博,MAB3306,Anti-MMP-3 Antibody, cross reacts w/hMMP-10, clone 55-2A4 merck millipore,默克密理博,MAB3306,Anti-MMP-3 Antibody, cross reacts w/hMMP-10, clone 55-2A4

merck millipore,默克密理博,MABF318,Anti-CD3ε (mouse) Antibody, PE/Cy5, clone 145-2C11 merck millipore,默克密理博,MABF318,Anti-CD3ε (mouse) Antibody, PE/Cy5, clone 145-2C11

merck millipore,默克密理博,ABN451,Anti-FE65 Antibody merck millipore,默克密理博,ABN451,Anti-FE65 Antibody


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部