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merck millipore,默克密理博,CBL234F,Anti-Cytokeratin Pan Antibody, clone C11, FITC conjugated
产品名称:Anti-Cytokeratin Pan Antibody, clone C11, FITC conjugated
产品型号:CBL234F
Anti-Cytokeratin Pan Antibody, clone C11, FITC conjugated is an antibody against Cytokeratin Pan for use in IH(P).
merck millipore,默克密理博,CBL234F,Anti-Cytokeratin Pan Antibody, clone C11, FITC conjugated
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Fg, B, H, R IH(P) M FITC Monoclonal Antibody 描述 产品目录编号 CBL234F 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Cytokeratin Pan Antibody, clone C11, FITC conjugated 产品信息 格式 FITC 演示 The conjugate is supplied as a 100 test vial in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. For flow cytometry we recommend using 10μL of conjugate per test. 应用 应用 Anti-Cytokeratin Pan Antibody, clone C11, FITC conjugated is an antibody against Cytokeratin Pan for use in IH(P). 主要应用 - Immunohistochemistry (Paraffin)
应用说明 Western blotting
Pan epithelial reactivity on frozen sections
Methanol/acetone fixed cultured epithelial cells
Suitable for staining formalin fixed paraffin wax sections following proteolytic enzyme digestion
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Epidermal carcinoma cell line A431 克隆 C-11 宿主 Mouse 特异性 The antibody reacts specifically with a wide range of normal, reactive and neoplastic epithelial tissues.
KNOWN SPECIES CROSS REACTIVITY: Positive with bovine, rat and frog同种型 IgG1 品种反应性 FrogBovineHumanRat 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002272.2
Entrez基因汇总 The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. 基因符号 - FLJ31692
- KRT4
- Cytokeratin-4
- CK-4
- CK4
- CYK4
- Keratin-4
- K4
UniProt编号 - P05783
- P19013
- P13647
- P02538
- P05787
- P13645
- P13646
UniProt汇总 FUNCTION: SwissProt: P05787 # Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
SIZE: 483 amino acids; 53704 Da
SUBUNIT: Heterotetramer of two type I and two type II keratins. keratin-8 associates with keratin-18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
PTM: Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
DISEASE:SwissProt: P05787 # Defects in KRT8 are a cause of cryptogenic cirrhosis [MIM:215600].
SIMILARITY: SwissProt: P05787 ## Belongs to the intermediate filament family.
MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store at +4°C protected from light. DO NOT FREEZE. For long term use and storage aliquot conjugate into small volumes and store at +4°C. 包装信息 数量 100 assays
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