merck millipore,默克密理博,CBL1337,Anti-PECAM-1 Antibody, clone 390

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M	IHC, FC	R	Purified	Monoclonal Antibody

描述
产品目录编号	CBL1337
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-PECAM-1 Antibody, clone 390
Alternate Names	CD31
背景信息	CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM1) is a type I integral membrane glycoprotein, and a member of the immunoglobulin superfamily of cell surface receptors. PECAM-1 is constitutively expressed on the surface of endothelial cells where it is concentrated at cell junctions. PECAM-1 is also expressed at low levels on all leukocytes and platelets. Homotypic interaction of CD31 is important in cell-cell interaction, cell-matrix interaction and signal transduction.

产品信息
格式	Purified
控制	Jurkat and Raji cells, tonsil tissue
演示	Protein A Purified mouse immunoglobulin in 100mM borate buffered saline, pH 8.0, containing no preservative.

应用
应用	Anti-PECAM-1 Antibody, clone 390 is an antibody against PECAM-1 for use in FC, IH & IP.
主要应用	Immunohistochemistry Flow Cytometry
应用说明	Flow Cytometry: 1 μg/10e6 cells. Immunohistochemistry: acteone fixed frozen tissue sections Immunoprecipitation Blocking of cell adhesion: CBL1337 inhibits aggregation of L cells transfected with a variant form of CD31 (DeLisser, 1993) Optimal working dilutions must be determined by the end user.

生物信息
免疫原品种	Mouse leukocyte cell line 32D
克隆	390
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rat
特异性	CBL1337 recognizes mouse PECAM-1, a 130-140 kDa type 1 integral membrane glycoprotein. This antibody has been shown to inhibit the aggregation of L cells transfected with a variant form of PECAM-1 (DeLisser, 1993).
同种型	IgG2aκ
品种反应性	Mouse
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_000442.3
基因符号	CD31/EndoCAM PECAM1 EndoCAM GPIIA PECAM-1 CD31
纯化方法	Protein A purfied
UniProt编号	P16284
UniProt汇总	FUNCTION: SwissProt: P16284 # This protein is a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. SIZE: 738 amino acids; 82536 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Long isoform predominates all tissues examined, isoform Delta12 was detected only in trachea and isoform Delta14-15 only in lung, isoform Delta14 was detected in all tissues examined with the strongest expression in heart. PTM: Phosphorylated on Ser and Tyr residues after cellular activation. SIMILARITY: SwissProt: P16284 ## Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

包装信息
数量	500 µg

merck millipore,默克密理博,CBL1337,Anti-PECAM-1 Antibody, clone 390

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