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描述 产品目录编号 14-779M 商名 - Upstate
描述 MKP5, active 概述 Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the
phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily
(MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members ofthis family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue
distribution and subcellular localization, and different modes of inducibility of their expression by extracellular
stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization
is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various
tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different
isoforms have been found for this gene.产品信息 演示 Protein in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. 应用 主要应用 - Phosphatase Assay
生物信息 来源 N-terminal 6His-tagged, recombinant, human MKP5, amino acids 320-end, expressed in E. coli. 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_007207
基因符号 - MKP5
- DUSP10
纯化方法 Purified using Ni2+/NTA agarose. UniProt编号 - Q9Y6W63
产品使用声明 质量保证 Routinely evaluated by the release of phosphate from the substrate 6,8-difluoro-4-methylumbelliferyl phosphate (DiFMUP) 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70°C 包装信息 数量 250 µg 包装 Also available in 10μg size as catalog # 14-779 and in 250 μg as catalog # 14-779M.
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