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描述 产品目录编号 AG533 品牌系列 Chemicon®
商名 - Chemicon
描述 ADAM 10, control peptide for AB19026 概述 Control peptide for Chemicon Cat. No. AB19026 (Rabbit anti-ADAM10). Peptide corresponds to amino acids 732-748 near the C-terminus. 产品信息 演示 Liquid in PBS, pH 7.2, containing 0.1% BSA and 0.02% sodium azide. 应用 主要应用 - Peptide Inhibition Assay
应用说明 Blocking: Use 1 μg control peptide per 1 μg antibody . Control peptide, because of it's small size (2-3 kDa), is not recommended for Western.
Optimal working dilutions must be determined by end user.生物信息 浓缩 0.2 mg/mL 来源 Synthetic peptide 品种 Human Entrez基因编号 - NM_001110.2
Entrez基因汇总 Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. 基因符号 - EC 3.4.24.81
- ADAM10
- CDw156
- CD156c
- HsT18717
- kuzbanian
- kuz
- MADM
- KUZ
UniProt编号 - O14672
UniProt汇总 FUNCTION: SwissProt: O14672 # Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala- -Val-77' to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity).
COFACTOR: Binds 1 zinc ion (By similarity).
SIZE: 748 amino acids; 84142 Da
SUBUNIT: Interacts with ephrin-A2 (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Intracytoplasmic membrane; Single-pass type I membrane protein. Note=Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi.
TISSUE SPECIFICITY: Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.
DOMAIN: SwissProt: O14672 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
PTM: The precursor is cleaved by a furin endopeptidase (By similarity).
SIMILARITY: Contains 1 disintegrin domain. & Contains 1 peptidase M12B domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µg
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