merck millipore,默克密理愽
  • merck millipore,默克密理博,AG324,GABA B Receptor R1, control peptide for AB1531

  • merck millipore,默克密理博,AG324,GABA B Receptor R1, control peptide for AB1531

    产品名称：GABA B Receptor R1, control peptide for AB1531
    产品型号：AG324


    merck millipore,默克密理博,AG324,GABA B Receptor R1, control peptide for AB1531

  • 产品介绍
  • merck millipore,默克密理博,AG324,GABA B Receptor R1, control peptide for AB1531

    描述
    产品目录编号 AG324
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 GABA B Receptor R1, control peptide for AB1531
    概述 Peptide from rat GABA B Receptor R1.
    产品信息
    演示 Liquid in PBS.
    应用
    主要应用
    • Cell Function Assay
    应用说明 For use in blocking the reactivity of AB1531.

    Optimal working dilution must be determined by the end user.
    生物信息
    浓缩 1.0 mg/mL
    品种 Rat
    Entrez基因编号
    • NM_021905.1
    • NM_001470.1
    • NM_021903.1
    • NM_021904.1
    Entrez基因汇总 Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.
    基因符号
    • GPRC3A
    • GABBR1
    • dJ271M21.1.1
    • GABBR1-3
    • GABAB(1e)
    • hGB1a
    • GABABR1
    • dJ271M21.1.2
    • Gb1
    • GABA-B-R1
    UniProt编号
    • Q9UBS5
    UniProt汇总 FUNCTION: SwissProt: Q9UBS5 # Isoform 1E function may be to regulate the availability of functional GABA-B-R1A/GABA-B-R2 heterodimers by competing for GABA-B-R2 dimerization. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.
    COFACTOR: Calcium. Required for high affinity binding to GABA.
    SIZE: 961 amino acids; 108320 Da
    SUBUNIT: Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABA-B-R2. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region.
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Colocalizes with ATF4 in hippocampal neuron dendritic membranes (By similarity). Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane. & Isoform 1E: Secreted (Probable).
    TISSUE SPECIFICITY: Highly expressed in brain and weakly in heart, small intestine and uterus. Mostly expressed in granular cell and molecular layer for isoform 1A and in Purkinje cells form isoform 1B. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland.
    DOMAIN: SwissProt: Q9UBS5 Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 2. The linker region between the transmembrane domain 3 (TM3) and the transmembrane domain 4 (TM4) probably play a role in the specificity for G-protein coupling.
    SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. & Contains 2 Sushi (CCP/SCR) domains.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AG324,GABA B Receptor R1, control peptide for AB1531

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