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描述 产品目录编号 AG11P 品牌系列 Chemicon®
商名 - Chemicon
描述 Carcinoembryonic Antigen Alternate Names - CEA
产品信息 演示 Liquid in 10 mM phosphate-Na, pH 7.1, 150 mM NaCl. No preservative. 生物信息 浓缩 0.795 mg/mL 纯度 98% by SDS-PAGE. 品种 Human Entrez基因编号 - NM_001712.3
- NM_001024912.1
Entrez基因汇总 This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined. 基因符号 - BGPI
- CEACAM1
- BGP-1
- BGP1
- BGP
- CD66a
UniProt编号 - P13688
UniProt汇总 SIZE: 526 amino acids; 57560 Da
SUBCELLULAR LOCATION: Isoform A: Cell membrane; Single-pass type I membrane protein. & Isoform B: Cell membrane; Single-pass type I membrane protein. & Isoform C: Cell membrane; Single-pass type I membrane protein. & Isoform G: Secreted. & Isoform H: Secreted. & Isoform I: Secreted.
DISEASE:SwissProt: P13688 # Loss or reduced expression is a major event in colorectal carcinogenesis. & Increased serum levels of BGP-1 are found in individuals suffering from hepatic disorders.
SIMILARITY: SwissProt: P13688 ## Belongs to the immunoglobulin superfamily. CEA family. & Contains 3 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 Ig-like V-type (immunoglobulin-like) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C for up to 6 months. 包装信息 数量 100 µg
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