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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABC248 描述 Anti-HPGD Antibody Alternate Names - 15-PGDH
- 15-hydroxyprostaglandin dehydrogenase [NAD(+)]
- Prostaglandin dehydrogenase 1
背景信息 The protein named HPGD, or also known as 15-PGDH, or Prostaglandin dehydrogenase 1, and encoded by the gene HPGD/PGDH1, is a protein necessary for the regulation of prostaglandin levels. Prostaglandins are potent inflammatory agents, thus their regulation is key for control inflammatory responses. HPGD works to mediate prostaglandin inactivation by catalyzing the NAD dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoin A4. Additionally, HPGD inhibits in vivo proliferation of colon cancer cells. HPGD is localized to the cytoplasm. HPGD is expressed in intestinal and colon tissues. HPGD is down regulated in colon cancer and thus is being examined as a therapeutic agent. Defects in HPGD may be associated with Hypertrophic osteoarthropathy, a disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. Other diseases associated with this gene’s defects are Crainoosteoarthropathy (swollen joint disease) and congenital nail clubbing where one has very large nails on the fingers and toes. 产品信息 格式 Affinity Purified 演示 Purified rabbit Polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect Prostaglandin dehydrogenase 1 using this rabbit polyclonal antibody, Anti-HPGD Antibody validated for use in western blotting & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected HPGD in human ileum tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human HPGD. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human Species Reactivity Note Human. Predicted to react with Primate, Chimpanzee, Monkey, Baboon, and Rabbit based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_000851.2
基因符号 - PGDH1
- HPGD
纯化方法 Affinity purified UniProt编号 - P15428
产品使用声明 质量保证 Evaluated by Western Blotting in Caco-2 cell lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected HPGD in 10 µg of Caco-2 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,09-247,Anti-RHEB1 Antibody
下一件merck millipore产品：merck millipore,默克密理博,574775,Swainsonine, Swainsona canescens - CAS 72741-87-8 - Calbiochem
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