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merck millipore,默克密理博,MAB1222A,Anti-Tryptase Antibody, Mast Cell, clone G3, Alkaline Phosphatase
产品名称：Anti-Tryptase Antibody, Mast Cell, clone G3, Alkaline Phosphatase
产品型号：MAB1222A
Anti-Tryptase Antibody, Mast Cell, clone G3, Alkaline Phosphatase is an antibody against Tryptase for use in WB, IH.
merck millipore,默克密理博,MAB1222A,Anti-Tryptase Antibody, Mast Cell, clone G3, Alkaline Phosphatase
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB M Alkaline Phosphatase Monoclonal Antibody 描述 产品目录编号 MAB1222A 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Tryptase Antibody, Mast Cell, clone G3, Alkaline Phosphatase 产品信息 格式 Alkaline Phosphatase 演示 In 0.05M Tris + 0.1M NaCl + 0.001M MgCl2 with 0.1% NaN3, pH=8.0. 应用 应用 Anti-Tryptase Antibody, Mast Cell, clone G3, Alkaline Phosphatase is an antibody against Tryptase for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunoblotting & immunohistochemistry at 1:200-1:1,000. For optimal results, tissues or cytospin preparations should be fixed in Carnoy's Fluid (60% ethanol, 30% chloroform, 10% glacial acetic acid). Not recommended for use on formaldehyde fixed tissue. May be used on thin sections prepared for ultrastructural analysis after fixation of tissue in a modified Karnovsky's reagent [Lab. Invest. (1988). 58:682-691].
Optimal working dilutions must be determined by end user.生物信息 克隆 G3 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Mast cell tryptase. Will show reactivity to basophils but to a lesser degree. 同种型 IgG1κ 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_003294.3
Entrez基因汇总 Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. 基因符号 - EC 3.4.21.59
- TPSAB1
- tryptase-I
- TPS2
- Tryptase-1
- TPSB1
- TPS1
- tryptase-III
UniProt编号 - Q15661
UniProt汇总 FUNCTION: SwissProt: P15157 # Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.| Q15661 # Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
SIZE: 275 amino acids; 30773 Da
SUBUNIT: Homotetramer.
SUBCELLULAR LOCATION: Secreted. Note=Released from the secretory granules upon mast cell activation.
DOMAIN:SwissProt: P15157
SIMILARITY: SwissProt: P15157 ## Belongs to the peptidase S1 family. Tryptase subfamily. & Contains 1 peptidase S1 domain. | Q15661 ## Belongs to the peptidase S1 family. Tryptase subfamily. & Contains 1 peptidase S1 domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at +2-8°C in undiluted aliquots for up to 6 months. 包装信息 数量 100 µL
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