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品种反应性 主要应用 宿主 格式 抗体类型 Ox, H, M, R, Eq WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABT45 描述 Anti-Claudin-5 Antibody Alternate Names - TMDVCF
- Claudin-5
- Transmembrane protein deleted in VCFS
背景信息 Claudin-5, a transmembrane protein deleted in velo-cardio-facial syndrome (TMVCF), seems to be involved in endothelial tight junctions. Claudin-5 has been exclusively found in the cell-cell borders of endothelial cells. Lower claudin-5 levels in sinusoidal endothelial cells could lead to their dysfunction during liver injuries. Levels of claudin-5 in tumor vessels could be a potential marker for hepatocellular carcinoma prognosis. The loss of claudin-5 function has been linked to carcinogenesis. 产品信息 格式 Affinity Purified 控制 - Human lung tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Claudin-5 Antibody detects level of Claudin-5 & has been published & validated for use in WB, IH(P). 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:800 dilution from a representative lot detected Clausin-5 in prostate tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Claudin-5 at the cytoplasmic domain. 表位 Cytoplasmic Domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes Claudin-5 at the cytoplasmic domain. 品种反应性 OxHumanMouseRatHorse Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat.
Predicted to react with Equine and Ox based on 100% sequence homology.抗体类型 Polyclonal Antibody Entrez基因编号 - NP_003268
Entrez基因汇总 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]. 基因符号 - TMVCF
- CLDN5
- AWAL
纯化方法 Affinity Purified UniProt编号 - O00501
UniProt汇总 FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity).
SUBUNIT STRUCTURE: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ (By similarity).
SUBCELLULAR LOCATION: Cell junction › tight junction. Cell membrane; Multi-pass membrane protein.
SEQUENCE SIMILARITIES: Belongs to the claudin family.产品使用声明 质量保证 Evaluated by Western Blot in human lung tissue lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected Claudin-5 in 10 µg of human lung tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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