merck millipore,默克密理愽
  • merck millipore,默克密理博,CBL431,Anti-N-Myc Antibody, clone IA8

  • merck millipore,默克密理博,CBL431,Anti-N-Myc Antibody, clone IA8

    产品名称：Anti-N-Myc Antibody, clone IA8
    产品型号：CBL431
    Anti-N-Myc Antibody, clone IA8 is a high quality Mouse Monoclonal Antibody for the detection of N-Myc & has been validated in WB & IHC.

    merck millipore,默克密理博,CBL431,Anti-N-Myc Antibody, clone IA8

  • 产品介绍
  • merck millipore,默克密理博,CBL431,Anti-N-Myc Antibody, clone IA8

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 CBL431
    Replaces CBL437
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-N-Myc Antibody, clone IA8
    产品信息
    格式 Purified
    演示 The monoclonal is presented at a concentration of 100μg/1ml in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
    应用
    应用 Anti-N-Myc Antibody, clone IA8 is a high quality Mouse Monoclonal Antibody for the detection of N-Myc & has been validated in WB & IHC.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Western blotting on detergent lysates from cells expressing N-myc.

    Immunohistochemical studies of N-myc on frozen sections.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Human N-myc sequence 334-343 + Cys.
    克隆 IA8
    宿主 Mouse
    特异性 The antibody reacts with a major peptide-blockable band at 62-64 kDa on western blots.
    同种型 IgG2b
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_005369.2
    Entrez基因汇总 This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. [provided by RefSeq].
    基因符号
    • BHLHE37
    • MYCN
    • NMYC
    • N-Myc
    UniProt编号
    • P04198
    UniProt汇总 FUNCTION: May function as a transcription factor.
    SIZE: 464 amino acids; 49561 Da
    SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an heterodimer with MAX. Interacts with KDM5A, KDM5B and HUWE1.
    SUBCELLULAR LOCATION: Nucleus.
    DEVELOPMENTAL STAGE: Expressed during fetal development.
    DISEASE: Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses.
    Defects in MYCN are the cause of Feingold syndrome; also known as oculodigitoesophagoduodenal syndrome (ODED). Feingold syndrome is characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability and limb malformations. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described.
    Defects in MYCN are the cause of microcephaly and digital abnormalities with normal intelligence.
    SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20C.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,CBL431,Anti-N-Myc Antibody, clone IA8

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