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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABT40 描述 Anti-MFAP-5 (MAGP2) Antibody Alternate Names - MAGP-2
- Microfibrillar-associated protein 5
- MFAP-5
- MP25
- Microfibril-associated glycoprotein 2
背景信息 Microfibril-associated protein 2 (MAGP-2), also known as microfibrillar associated protein 5 (MFAP-5), is a multifunctional secreted protein that acts as a promoter of tumor cell survival and angiogenesis. Through alphaVbeta3 integrin-mediated signaling, it is suggested that MAGP2 may provide a potential mechanistic link between MAGP2 and angiogenesis, as well as patient survival. Based on a high level of homology between MAGP (MFAP-2) and MAGP-2, both proteins are shown to bind to and activate Notch-1, as well as mediate the subsequent release of the Notch-1 extracellular domain. 产品信息 格式 Affinity Purified 控制 - Human skeletal muscle tissue lysate.
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-MFAP-5 (MAGP2) Antibody is validated for use in WB for the detection of MFAP-5 (MAGP2). 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human MFAP-5 (MAGP-2). 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human Species Reactivity Note Tested and passed on Human. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_003471
Entrez基因汇总 This gene encodes a 25-kD microfibril-associated glycoprotein which is rich in serine and threonine residues. It lacks a hydrophobic carboxyl terminus and proline-, glutamine-, and tyrosine-rich regions, which are characteristics of a related 31-kDa microfibril-associated glycoprotein (MFAP2). The close similarity between these two proteins is confined to a central region of 60 aa where precise alignment of 7 cysteine residues occurs. The structural differences suggest that this encoded protein has some functions that are distinct from those of MFAP2. 基因符号 - MAGP2
- MFAP5
纯化方法 Affinity Purified UniProt编号 - Q13361
UniProt汇总 FUNCTION: Component of the elastin-associated microfibrils.
SUBCELLULAR LOCATION: Secreted > extracellular space > extracellular matrix.产品使用声明 质量保证 Evaluated by Western Blot in human skeletal muscle tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected MFAP-5 (MAGP-2) in skeletal muscle tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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