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品种反应性 主要应用 宿主 格式 抗体类型 Chp, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABT116 描述 Anti-FucT-VI Antibody Alternate Names - Galactoside 3-L-Fucosyltransferase
- Alpha-(1,3)-Fucosyltransferase
- Fucosyltransferase 6
- Fucosyltransferase Vi
- Fuc-Tvi
- Fuct-Vi
背景信息 Alpha-(1,3)-fucosyltransferase 6 (FucT-VI) is a member of the glycosyltransferase family of proteins which are involved in a glycosylation pathway that attaches fucose to Lewis epitopes of target molecules. This type of post-translational modification allows modified (fucosylated) molecules to recognize specific target substrates. Fucosyltransferases may therefore play an important role in communication at the cell surface, and may be involved in selectin-mediated cell recognition and adhesion processes. FucT-VI is expressed in colon, liver, kidney, small intestine, uterus, and bladder. 产品信息 格式 Affinity Purified 控制 - Human Kidney Tissue Lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-FucT-VI Antibody is an antibody against FucT-VI for use in Western Blotting. 主要应用 - Western Blotting
应用说明 Western Blot Analysis: 0.5 µg/mL from a representative lot detected FucT-VI on 10 µg of transfected lysate and did not detect the non transfected lysate. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the lumenal region of human FucT-VI. 表位 Lumenal region 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes FucT-VI at the lumenal region. 品种反应性 ChimpanzeeHuman Species Reactivity Note Demonstrated to react with Human. Predicted to react with Chimpanzee based on 100% sequence homology. No homology to Rat and Mouse was found. 抗体类型 Polyclonal Antibody Entrez基因编号 - Np_000141
Entrez基因汇总 The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. 基因符号 - Fct3A
- Fut6
纯化方法 Affinity purified UniProt编号 - P51993
UniProt汇总 FUNCTION: Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates.
CATALYTIC ACTIVITY: GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.
PATHWAY: Protein modification; protein glycosylation.
SUBCELLULAR LOCATION: Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein. Note: Membrane-bound form in trans cisternae of Golgi.
TISSUE SPECIFICITY: Kidney, liver, colon, small intestine, bladder, uterus and salivary gland.
POLYMORPHISM: Expression of alpha(1,3)-fucosyltransferase in plasma can vary among different populations. 9% of individuals on the isle of Java (Indonesia) do not express this enzyme. Ninety-five percent of plasma alpha(1,3)-fucosyltransferase-deficient individuals have Lewis negative phenotype on red cells, suggesting strong linkage disequilibrium between these two traits. Variations in FUT6 are responsible for plasma alpha(1,3)-fucosyltransferase deficiency [MIM:613852].
SEQUENCE SIMILARITIES: Belongs to the glycosyltransferase 10 family.产品使用声明 质量保证 Evaluated by Western Blot in human kidney tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected FucT-VI on 10 µg of human kidney tissue lysate.储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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