merck millipore,默克密理愽
  • merck millipore,默克密理博,05-354,Anti-Clusterin α chain (human) Antibody, clone 41D

  • merck millipore,默克密理博,05-354,Anti-Clusterin α chain (human) Antibody, clone 41D

    产品名称：Anti-Clusterin α chain (human) Antibody, clone 41D
    产品型号：05-354
    Anti-Clusterin α chain (human) Antibody, clone 41D is an antibody against Clusterin α chain (human) for use in IC, IH, IH(P) & WB.

    merck millipore,默克密理博,05-354,Anti-Clusterin α chain (human) Antibody, clone 41D

  • 产品介绍
  • merck millipore,默克密理博,05-354,Anti-Clusterin α chain (human) Antibody, clone 41D

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, ICC, IHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-354
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Clusterin α chain (human) Antibody, clone 41D
    Alternate Names
    • sulfated glycoprotein 2
    • Apolipoprotein J
    • Complement cytolysis inhibitor
    • Complement-associated protein SP-40,40
    • Ku70-binding protein 1
    • Testosterone-repressed prostate message 2
    • aging-associated protein 4
    • clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)
    • complement lysis inhibitor
    • complement-associated protein SP-40
    • testosterone-repressed prostate message 2
    • apolipoprotein J)
    • complement lysis inhibitor
    背景信息 Clusterin is also known as apolipoprotein J, complement lysis inhibitor, gp80, glycoprotein III, SGP-2, SP 40-40, TRPM2 and T64. It is a ubiquitous multifunctional protein of 80kD comprising of two disulfide-linked subunits, alpha and beta, and capable of interacting with a broad range of molecules. It is implicated in numerous biological processes including sperm maturation, lipid transport, regulation of the complement cascade, membrane recycling, cell death, immune regulation, cell adhesion and morphological transformation. In pathological conditions, it is an amyloid associated protein co-localising with fibrillar deposits in systemic and localised amyloid disorders. In Alzheimer ’s disease, clusterin is present in amyloid plaques and cerebrovascular deposits. In breast cancers, clusterin expression was found to correlate with tumour size. Clusterin is also implicated with endometrial cancers, myocardial infarction, renal diseases and atherosclerosis.
    产品信息
    格式 Purified
    控制
    • HeLa cell lysate.
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, with 0.05% sodium azide. Frozen at -20°C.
    应用
    应用 Anti-Clusterin α chain (human) Antibody, clone 41D is an antibody against Clusterin α chain (human) for use in IC, IH, IH(P) & WB.
    主要应用
    • Western Blotting
    • Immunocytochemistry
    • Immunohistochemistry
    应用说明 Immunohistochemistry:
    Previous lots of this antibody at 5 µg/mL detected clusterin in paraffin embedded human brain sections.
    生物信息
    免疫原品种 Native clusterin purified from human serum. Clone 41D.
    克隆 41D
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes human clusterin α chain, Mr 40 kDa, and precursor protein.
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_203339
    基因符号
    • SGP2
    • CLU
    • SP-40
    • MGC24903
    • NA1/NA2
    • SGP-2
    • AAG4
    • KUB1
    • APOJ
    • CLI
    • TRPM-2
    • TRPM2
    • Apo-J
    纯化方法 Protein G purfied
    UniProt编号
    • P10909
    UniProt汇总 FUNCTION: SwissProt: P10909 # Not yet clear. It is known to be expressed in a variety of tissues and it seems to be able to bind to cells, membranes and hydrophobic proteins. It has been associated with programmed cell death (apoptosis).
    SIZE: 449 amino acids; 52495 Da
    SUBUNIT: Antiparallel disulfide-linked heterodimer. Interacts with CLUAP1.
    SUBCELLULAR LOCATION: Secreted.
    SIMILARITY: SwissProt: P10909 ## Belongs to the clusterin family.
    产品使用声明
    质量保证 Routinely evaluated on RIPA lysates from HeLa cells or MCF-7 cell lysates.

    Western Blot Analysis:
    0.5-2 µg/mL of a previous lot detected human clusterin α chain in RIPA lysates from HeLa cells; previous lots detected the protein in human serum and MCF-7 cell lysates
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.

    Handling Recommendations:
    Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-354,Anti-Clusterin α chain (human) Antibody, clone 41D

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