• merck millipore,默克密理博,ABS48,Anti-phospho-SMAD3 (Ser213) Antibody
  • merck millipore,默克密理博,ABS48,Anti-phospho-SMAD3 (Ser213) Antibody

    产品名称:Anti-phospho-SMAD3 (Ser213) Antibody
    产品型号:ABS48
    Anti-phospho-SMAD3 (Ser213) Antibody detects level of phospho-SMAD3 (Ser213) & has been published & validated for use in Western Blotting.

    merck millipore,默克密理博,ABS48,Anti-phospho-SMAD3 (Ser213) Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABS48,Anti-phospho-SMAD3 (Ser213) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Ch, HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABS48
    描述 Anti-phospho-SMAD3 (Ser213) Antibody
    Alternate Names
    • hSMAD3
    • Mothers against decapentaplegic homolog 3
    • MAD homolog 3
    • Mad3
    • Mothers against DPP homolog 3
    • hMAD-3
    • JV15-2
    • SMAD family member 3
    • SMAD 3
    • Smad3
    背景信息 Members of the SMAD family of signal transduction molecules are components of a critical intracellular pathway that transmits TGF-β signals from the cell surface into the nucleus. Three distinct classes of SMADs have been defined: the receptor-regulated SMADs (R-SMADs), which include Smad1, 2, 3, 5 and 8, the common-mediator SMAD (co-SMAD), SMAD4, and the antagonistic or inhibitory SMADs (I-SMADs), SMAD6 and 7. Once in the nucleus, SMADs can target a variety of DNA binding proteins to regulate transcriptional responses. Following stimulation by TGF-β, SMAD2 and SMAD3 become phosphorylated at their carboxyl termini (Ser465 and 467 on SMAD2; Ser423 and 425 on SMAD3) by TGF-β Receptor I. Phosphorylated SMAD 2/3 can complex with SMAD4, translocate to the nucleus and regulate gene expression.
    产品信息
    格式 Affinity Purified
    控制
    • Untreated and TGF beta treated HaCat cell lysates
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-phospho-SMAD3 (Ser213) Antibody detects level of phospho-SMAD3 (Ser213) & has been published & validated for use in Western Blotting.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human SMAD3 phosphorylated at Ser213.
    表位 Phosphorylated Ser213
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes SMAD3 phosphorylated at Ser213.
    品种反应性 ChickenHuman
    Species Reactivity Note Demonstrated to react with Human. Predicted to react with Chicken based on 100% sequence homology. Other homologies: Bovine, Xenopus, and Zebrafish (90% sequence homology).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_005893
    基因符号
    • MADH3
    • SMAD3
    纯化方法 Affinity purified
    UniProt编号
    • P84022
    产品使用声明
    质量保证 Evaluated by Western Blot in untreated and TGF beta treated HaCat cell lysates.

    Western Blot Analysis: 2 µg/mL of this antibody detected SMAD3 on 10 µg of untreated and TGF beta treated HaCat cell lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,ABS48,Anti-phospho-SMAD3 (Ser213) Antibody

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