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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABS21 描述 Anti-Surfactant Protein B Antibody Alternate Names - SP-B
- Pulmonary surfactant-associated protein B
- 18 kDa pulmonary-surfactant protein
- Pulmonary surfactant-associated proteolipid SPL(Phe)
背景信息 Surfactant Protein B (SP-B) is mostly composed of phospholipids, but also incorporates essential proteins. It is necessary for pulmonary surfactant function and the alveolar type 2 cell phenotype. SP-B deficiency has been known to cause congenital pulmonary alveolar proteinosis. SP-B is thought to protect lungs against endotoxin-induced inflammation. SP-B could be used as a clinical marker in chronic heart failure. 产品信息 格式 Affinity Purified 控制 - Human lung tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-Surfactant Protein B Antibody is validated for use in WB, IH(P) for the detection of Surfactant Protein B. 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: 1:200 dilution from a representative lot detected Surfactant protein B in clara cells in normal rat lung tissue. 生物信息 免疫原品种 GST-tagged recombinant protein corresponding to human Surfactant Protein B at the Saposin B-type 2 domain. 表位 Saposin B-type 2 domain 宿主 Rabbit 特异性 This antibody recognizes Surfactant Protein B at the Saposin B-type 2 domain. 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_942140
Entrez基因汇总 This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified. 基因符号 - SMDP1
- SFTPB
- SP-B
- SFTP3
- Phe
- PSP-B
- SFTB3
纯化方法 Affinity purified UniProt编号 - P07988
UniProt汇总 FUNCTION: Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
SIZE: 381 amino acids; 42117 Da
SUBUNIT: Homodimer; disulfide-linked.
SUBCELLULAR LOCATION: Secreted, extracellular space.
DISEASE: Defects in SFTPB are the cause of pulmonary surfactant metabolism dysfunction type 1 (SMDP1) [MIM:265120]; also called pulmonary alveolar proteinosis due to surfactant protein B deficiency. Inborn errors of pulmonary surfactant metabolism are genetically heterogeneous disorders resulting in severe respiratory insufficiency or failure in full-term neonates or infants. These disorders are associated with various pathologic entities, including pulmonary alveolar proteinosis (PAP), desquamative interstitial pneumonitis (DIP), or cellular non- specific interstitial pneumonitis (NSIP).
SIMILARITY: Contains 1 saposin A-type domain. & Contains 3 saposin B-type domains.
MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).产品使用声明 质量保证 Evaluated by Western Blot in human lung tissue lysate.
Western Blot Analysis: 1:5,000 dilution of this antibody detected Surfactant Protein B on 10 µg of human lung tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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