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品种反应性 主要应用 宿主 格式 抗体类型 B, H, M, Rhesus Macaque, Eq, Chp, Ca WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABS14 描述 Anti-PKA RII Beta Antibody Alternate Names - cAMP-dependent protein kinase type II-beta regulatory subunit
- protein kinase, cAMP-dependent, regulatory, type II, beta
- cAMP-dependent protein kinase type II-beta regulatory chain
背景信息 PKA RII Beta is a type two regulatory chain which mediates membrane association by binding to anchoring proteins, including the MAP2 kinase. When the enzyme is inactive there are two regulatory chains and two catalytic chains. PKA RII Beta is activated by cAMP and produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. 产品信息 格式 Affinity Purified 控制 - Human brain tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-PKA RII Beta Antibody is an antibody against PKA RII Beta for use in WB. 主要应用 - Western Blotting
应用说明 Western Blot Analysis: 0.5 µg/mL from a previous lot detected PKA RII Beta on 10 µg of mouse brain tissue lysate. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human PKA RII Beta at the cAMP2 domain. 表位 cAMP2 domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes PKA RII Beta at the cAMP2 domain. 品种反应性 BovineHumanMouseRhesus MacaqueHorseChimpanzeeCanine Species Reactivity Note Demonstrated to react with human and mouse. Predicted to react with rhesus macaque, equine, chimpanzee, canine, and bovine based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_002727
Entrez基因汇总 cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq]. 基因符号 - RII-BETA
- PRKAR2
- PRKAR2B
纯化方法 Affinity purified UniProt编号 - P31323
UniProt汇总 FUNCTION: Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
SUBUNIT STRUCTURE: The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules.
TISSUE SPECIFICITY: Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
PTM: Phosphorylated by the activated catalytic chain. Ref.5 Ref.6 Ref.8 Ref.9
SEQUENCE SIMILARITIES: Belongs to the cAMP-dependent kinase regulatory chain family.
Contains 2 cyclic nucleotide-binding domains.产品使用声明 质量保证 Evaluated by Western Blot in human brain tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected PKA RII Beta on 10 µg of human brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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