merck millipore,默克密理博,ABN425,Anti-DISC1 Antibody

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M	IHC, WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	ABN425
描述	Anti-DISC1 Antibody
Alternate Names	Disrupted in schizophrenia 1 homolog
背景信息	Disrupted in schizophrenia 1 protein (DISC1) is involved in the regulation of multiple aspects of embryonic and adult neurogenesis. DISC1 may play a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. DISC1 is shown to inhibit the activation of AKT-mTOR signaling upon interaction with CCDC88A. DISC1 is required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Additionally, DISC1 is suggested to regulate the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. DISC1 has been shown to participates in the Wnt-mediated neural progenitor proliferation as a positive regulator and may have a role, together with PCNT, in the microtubule network formation. DICS1 is highly expressed in the dentate gyrus of the hippocampus. It is also expressed in the temporal and parahippocampal cortices and cells of the white matter. Expression rises within the dentate gyrus and temporal cortex from the neonatal period to infancy, declines markedly in adolescence, and declines further with aging.

产品信息
格式	Affinity Purified
演示	Purified rabbit polyclonal in buffer containing PBS without preservatives.

应用
应用	Anti-DISC1 Antibody detects level of DISC1 & has been published & validated for use in DISC1.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: A representative lot detected DISC1 in mouse hippocampus tissue (Kuroda, K., et al. (2011). Human Mole. Gene. 20(23):4666-4683).

生物信息
免疫原品种	Recombinant protein corresponding to mouse DISC1.
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
品种反应性	Mouse
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_777278
基因符号	Disc1
纯化方法	Affinity purified
UniProt编号	Q811T9

产品使用声明
质量保证	Evaluated by Western Blotting in mouse wild type P0 brain tissue lysate. Western Blotting Analysis: A 1:1,000 dilution of this antibody detected DISC1 in 10 µg of mouse wild type P0 brain and mouse knock out P0 brain tissue lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

包装信息
数量	100 µL

merck millipore,默克密理博,ABN425,Anti-DISC1 Antibody

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