merck millipore,默克密理愽
  • merck millipore,默克密理博,ABN38,Anti-RAB35 Antibody

  • merck millipore,默克密理博,ABN38,Anti-RAB35 Antibody

    产品名称：Anti-RAB35 Antibody
    产品型号：ABN38
    This Anti-RAB35 Antibody is validated for use in WB, IH(P) for the detection of RAB35.

    merck millipore,默克密理博,ABN38,Anti-RAB35 Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABN38,Anti-RAB35 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Eq, H, R, CaWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABN38
    描述 Anti-RAB35 Antibody
    Alternate Names
    • Ras-related protein Rab-1C
    • Ras-related protein Rab-35
    • GTP-binding protein RAY
    背景信息 RAB35 is a member of the Rab GTPases identified in the human genome. It is ubiquitously expressed and regulates a fast endocytotic recycling events associated with the terminal steps of cytokinesis, the formation of immunological synapse, and peptide loading onto major histocompatibility complex III molecules. RAB35 also plays a significant role in the formation of the immunological synapse (IS) between peptide-loaded antigen presenting cells (APCs) and T cells.
    产品信息
    格式 Affinity Purified
    控制
    • Human brain tissue lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-RAB35 Antibody is validated for use in WB, IH(P) for the detection of RAB35.
    主要应用
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected RAB35 in normal human brain tissue.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to the C-terminus of human RAB35.
    表位 C-terminus
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes RAB35 at the C-terminus.
    品种反应性 HorseHumanRatCanine
    Species Reactivity Note Demonstrated to react with Human and Rat. Predicted to react with Canine and Equine based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_006852
    基因符号
    • RAY
    • RAB35
    • RAB1C
    纯化方法 Affinity purified
    UniProt编号
    • Q15286
    UniProt汇总 FUNCTION: In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge.

    SUBUNIT STRUCTURE: Interacts with DENND1A and DENND1B in a nucleotide-dependent manner. The low binding to DENND1C is nucleotide-independent. All 3 DENND1 act as GEFs for RAB35 and thus activate the protein.

    SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side Potential. Membrane › clathrin-coated pit. Cytoplasmic vesicle › clathrin-coated vesicle. Endosome. Melanosome. Note: Present on sorting endosomes and endosomal tubules. Tends to be enriched in PIP2-positive cell membrane domains. During mitosis, associated with the plasma membrane and present at the ingressing furrow during early cytokinesis as well as at the intercellular bridge later during cytokinesis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

    SEQUENCE SIMILARITIES: Belongs to the small GTPase superfamily. Rab family.
    产品使用声明
    质量保证 Evaluated by Western Blot in human brain tissue lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected RAB35 on 10 µg of human brain tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABN38,Anti-RAB35 Antibody

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