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品种反应性 主要应用 宿主 格式 抗体类型 B, H, R, M, Chp, Rhesus Macaque, Ca WB Gp Serum Polyclonal Antibody 描述 产品目录编号 ABN35 描述 Anti-Neurexin-1-alpha Antibody Alternate Names - Neurexin1
- Neurexin-1-alpha
- Neurexin I-alpha
背景信息 Neurexins are heavily glycosylated and processed neuronal transmembrane cell surface proteins likely involved in cell recognition and adhesion (see review by Missler & Sudhof, 1998). Antibody Anti-Neurexin-1-alpha (ABN35) was made against a peptide immunogen corresponding to a stretch of amino acids in the extracellular domain of human Neurexin-1-alpha (Uniprot Q9ULB1). Although the theoretical full length of Neurexin-1-alpha is 161 kDa, the protein detected in human brain lysates may show a band around 170 kDa and additional bands around 45 kDa as a possible result of the posttranslational processing previously reported. 产品信息 格式 Serum 控制 - Human cerebellum tissue lysate
演示 Guinea pig polyclonal in serum containing 0.05% sodium azide. 应用 应用 This Anti-Neurexin-1-alpha Antibody is validated for use in WB, IH(P) for the detection of Neurexin-1-alpha. 主要应用 - Western Blotting
应用说明 Western Blot Analysis: A 1:1,000 dilution from a representative lot detected Neurexin-1-alpha on 10 µg of human brain tissue lysate.
Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected Neurexin-1-alpha in human brain tissue.生物信息 免疫原品种 Bovine thyroglobulin-conjugated linear peptide corresponding to human Neurexin-1-alpha at the extracellular laminin G-like 3 domain. 表位 Extracellular laminin G-like 3 domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Guinea Pig 特异性 This antibody recognizes Neurexin-1-alpha at the extracellular laminin G-like 3 domain. 品种反应性 BovineHumanRatMouseChimpanzeeRhesus MacaqueCanine Species Reactivity Note Demonstrated to react with Human, Rat, and Mouse. Predicted to react with Chimpanzee, Rhesus Macaque, Canine, and Bovine based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_004792
Entrez基因汇总 Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human (NRXN1 and NRXN3). By using alternate promoters, splice sites and exons, predictions of hundreds or even thousands of distinct mRNAs have been made. Most transcripts use the upstream promoter and encode alpha-neurexin isoforms; fewer transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. Alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and they interact with neurexophilins. Beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. The RefSeq Project has decided to create only a few representative transcript variants of the multitude that are possible. [provided by RefSeq]. 基因符号 - NRXN1
纯化方法 Unpurified UniProt编号 - Q9ULB1
UniProt汇总 FUNCTION: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.
SUBUNIT STRUCTURE: The cytoplasmic C-terminal region binds to CASK, CASKIN1 and APBA1. The laminin G-like domain 2 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan and to alpha-latroxin. Interacts with SYT13 and SYTL1 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein Potential.
TISSUE SPECIFICITY: Heart and brain.
PTM: N- and O-glycosylated (By similarity).
SEQUENCE SIMILARITIES: Belongs to the neurexin family.
Contains 3 EGF-like domains.
Contains 6 laminin G-like domains.
SEQUENCE CAUTION: The sequence BAA25504.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.产品使用声明 质量保证 Evaluated by Western Blot in human cerebellum tissue lysate.
Western Blot Analysis: A 1:1,000 dilution from a representative lot detected Neurexin-1-alpha in human cerebellum tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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