merck millipore,默克密理博,ABE801,Anti-PIAS4 Antibody

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	IHC, WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	ABE801
描述	Anti-PIAS4 Antibody
Alternate Names	PIAS-gamma E3 SUMO-protein ligase PIAS4 PIASy Protein inhibitor of activated STAT protein 4 Protein inhibitor of activated STAT protein gamma
背景信息	E3 SUMO-protein ligase PIAS4, also known as PIASy or Protein inhibitor of activated STAT protein 4 or Protein inhibitor of activated STAT protein gamma (PIAS-gamma) and encoded by the gene name PIAS4 or PIASG, plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS4. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS4 interacts with p53 and blocks its ability to induce Bax and p21 transcription. PIAS4 is also important in the control of the ubiquitin-dependent proteasomal degradation of the Ets-1 transcription facto. PIAS4 has been implicated in the DNA-damage response pathway and is thought to work in combination with PIAS1 for the productive association of 53BP1, BRCA1 and RNF168.

产品信息
格式	Affinity Purified
演示	Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

应用
应用	Anti-PIAS4 Antibody detects level of PIAS4 & has been published & validated for use in PIAS4.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: 5 μg/mL from a representative lot detected PIAS4 in rat brain tissue.

生物信息
免疫原品种	KLH-conjugated synthetic peptide corresponding to the N-terminus of human PIAS4.
表位	N-terminus
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	This antibody is predicted to not cross-react with other members of the PIAS family.
品种反应性	Human
抗体类型	Polyclonal Antibody
基因符号	PIASG PIAS4
纯化方法	Antigen Affinity purified
UniProt编号	Q8N2W9

产品使用声明
质量保证	Evaluated by Western Blotting in rat brain tissue lysate with and without blocking peptide. Western Blotting Analysis: 1 μg/mL of this antibody detected PIAS4 in rat brain tissue lysate with and without blocking peptide.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,ABE801,Anti-PIAS4 Antibody

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