- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,ABE55,Anti-Maf-B Antibody
产品名称：Anti-Maf-B Antibody
产品型号：ABE55
Anti-Maf-B Antibody is a Rabbit Polyclonal Antibody for detection of Maf-B also known as v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) & has been validated in WB, ICC.
merck millipore,默克密理博,ABE55,Anti-Maf-B Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M ICC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 ABE55 描述 Anti-Maf-B Antibody Alternate Names - Kreisler maf-related leucine zipper homolog
- v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
- MAFB/Kreisler basic region/leucine zipper transcription factor
- transcription factor MafB
- Kreisler (mouse) maf-related leucine zipper homolog
背景信息 Transcription factor MafB (Maf-B) belongs to the bZIP family as a part of the MAF subfamily and contains a characteristic bZIP domain. Maf-B can function as either a transcriptional activator or repressor. It regulates erythroid differentiation through its interaction with and negative regulation of EST-1 activity. Maf-B is a critical factor in the differentiation of islet beta cells, alpha and beta cells, macrophage, monocytic, and podocyte cells. It is involved in macrophage expression and maturation of F4/80, and regulates renal development and survival of renal tubules. Interaction with SUMO regulates the transcriptional activity of Maf-B along with its function in determining macrophage fate. Studies have shown that, relative to cell context, Maf-B can act as either a tumor or an oncogene suppressor. 产品信息 格式 Serum 控制 - L6 cell lysate
演示 Rabbit polyclonal serum containing 0.5% sodium azide. 应用 应用 Anti-Maf-B Antibody is a Rabbit Polyclonal Antibody for detection of Maf-B also known as v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) & has been validated in WB, ICC. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected Maf-B in NIH/3T3 cells. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Maf-B. 宿主 Rabbit 同种型 IgG 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with human, mouse, and rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_005452
Entrez基因汇总 The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns. [provided by RefSeq]. 基因符号 - Maf-B
- MAFB1
- KRML
- maf-B
纯化方法 Unpurified UniProt编号 - Q9Y5Q3
UniProt汇总 FUNCTION: Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context.
SUBUNIT STRUCTURE: Homodimer or heterodimer with other bHLH-Zip transcription factors. Binds DNA as a homodimer or a heterodimer. Forms homo- and heterodimers with FOS, FOSB and FOSL2, but not with JUN proteins (JUN, JUNB and JUND). Interacts with PAX6; the interaction is direct. Interacts with ETS1 and LRP1 (By similarity). Interacts with the intracellular cytoplasmic domain of LRP1 (LRPICD); the interaction results in a moderate reduction of MAFB transcriptional potential.
SUBCELLULAR LOCATION: Nucleus (By similarity).
TISSUE SPECIFICTY: Ubiquitous.
DOMAIN: The leucine-zipper domain is involved in the interaction with LRPICD.
PTM: Phosphorylated by GSK3 and MAPK13 on serine and threonine residues Probable.
Sumoylated. Sumoylation on Lys-32 and Lys-297 stimulates its transcriptional repression activity and promotes macrophage differentiation from myeloid progenitors (By similarity).
SEQUENCE SIMILARITIES: Belongs to the bZIP family. Maf subfamily.
Contains 1 bZIP domain.产品使用声明 质量保证 Evaluated by Western Blot in L6 cell lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected Maf-B on 10 µg of L6 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,14-653,EphA1 Protein, active, 10 µg
下一件merck millipore产品：merck millipore,默克密理博,HTS123M,ChemiScreen™ Recombinant Human BB1 Bombesin/Neuromedin B Receptor Membrane Preparation
相关产品
merck millipore,默克密理博,07-1382,Anti-eEF2 (CT) Antibody
merck millipore,默克密理博,14-760M,Ret (V804M) Protein, active, 250 µg
merck millipore,默克密理博,05-714,Anti-Lamin A/C Antibody, clone 14
merck millipore,默克密理博,AB2234,Anti-Norepinephrine Transporter Antibody
merck millipore,默克密理博,14-653,EphA1 Protein, active, 10 µg
merck millipore,默克密理博,ABS88,Anti-phospho-mTOR (Thr2164) Antibody
merck millipore,默克密理博,PP100-KC,Mouse IgG1 (1mg) KC
merck millipore,默克密理博,MABN223,Anti-MANF Antibody, clone 2D9.2
merck millipore,默克密理博,419820,ITK Inhibitor, BMS-509744 - CAS 439575-02-7 - Calbiochem