merck millipore,默克密理愽
  • merck millipore,默克密理博,ABE498,Anti-Lysine-specific demethylase 7 Antibody

  • merck millipore,默克密理博,ABE498,Anti-Lysine-specific demethylase 7 Antibody

    产品名称：Anti-Lysine-specific demethylase 7 Antibody
    产品型号：ABE498
    Detect Lysine-specific demethylase 7 using this rabbit polyclonal antibody, Anti-Lysine-specific demethylase 7 Antibody validated for use in western blotting.

    merck millipore,默克密理博,ABE498,Anti-Lysine-specific demethylase 7 Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABE498,Anti-Lysine-specific demethylase 7 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABE498
    描述 Anti-Lysine-specific demethylase 7 Antibody
    Alternate Names
    • JmjC domain-containing histone demethylation protein 1D
    • Lysine-specific demethylase 7
    背景信息 Lysine-specific demethylase 7, also known as JmjC domain-containing histone demethylation protein 1D, and encoded by the gene JHDM1D/KDM7/KIAA1718, is an important histone demethylase particularly for brain development. JHDM1D specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. JHDM1D also specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. JHDM1D also demethylates H3K9me2 in absence of H3K4me3 and JHDM1D has activity toward H4K20Me1 only when the nucleosome is used as a substrate and when not the histone octamer is used as substrate. JHDM1D is located in the nucleus and widely expressed but lowered expression is observed in glial cells and lymphoid cells. JHDM1D demonstrates tumor suppression by regulating angiogenesis factors when overexpression under starvation conditions in certain cancers, thus JHDM1D is being examined as a potential anti-cancer target.
    产品信息
    格式 Affinity Purified
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect Lysine-specific demethylase 7 using this rabbit polyclonal antibody, Anti-Lysine-specific demethylase 7 Antibody validated for use in western blotting.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human Lysine-specific demethylase 7.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody is expected to cross react with two known isoforms of Lysine-specific demethylase 7 based upon immunogen design.
    品种反应性 MouseHuman
    Species Reactivity Note Demonstrated to react with Human and Mouse. Predicted to react with Canine, Mouse, Rhesus Macaque, Chimpanzee Giant Panda, and Marmoset based upon sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_085150
    基因符号
    • KDM7
    • JHDM1D
    纯化方法 Affinity purified
    UniProt编号
    • Q6ZMT4
    产品使用声明
    质量保证 Evaluated by Western Blotting in HEK293 cell lysate.

    Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Lysine-specific demethylase 7 in 10 µg of HEK293 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABE498,Anti-Lysine-specific demethylase 7 Antibody

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