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品种反应性 主要应用 宿主 格式 抗体类型 H ICC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-610 品牌系列 Upstate
商名 - Upstate
描述 Anti-Peroxiredoxin 2 Antibody 产品信息 格式 Serum 演示 antiserum with 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 This Anti-Peroxiredoxin 2 Antibody is validated for use in WB, IC for the detection of Peroxiredoxin 2. 主要应用 - Immunocytochemistry
- Western Blotting
生物信息 免疫原品种 peptide corresponding to amino acids 103-114 (LLADVTRRLSED) of human Peroxiredoxin 2 宿主 Rabbit 特异性 Peroxiredoxin 2 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_005809 and others
Entrez基因汇总 This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 2.7 angstroms. Transcript variants encoding distinct isoforms have been identified for this gene. 基因符号 - Peroxiredoxin-2
- PRDX2
- TDPX1
- MGC4104
- torin
- PRP
- NKEFB
- NKEF-B
- PRXII
- TSA
纯化方法 Serum UniProt编号 - P32119
UniProt汇总 FUNCTION: SwissProt: P32119 # Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).
SIZE: 198 amino acids; 21892 Da
SUBUNIT: Homodimer; disulfide-linked, upon oxidation. May be found as a toroid-shaped decamer composed of 5 dimers, depending on pH and calcium concentration. Interacts with TIPIN.
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: SwissProt: P32119 ## Belongs to the ahpC/TSA family.
MISCELLANEOUS: The active site is the redox-active Cys-51 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-172-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin. & Inactivated upon oxidative stress by overoxidation of Cys-51 to Cys-SO(2)H and Cys-SO(3)H. Cys-SO(2)H is retroreduced to Cys-SOH after removal of H(2)O(2), while Cys-SO(3)H may be irreversibly oxidized.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from LNCap cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 50 µL
上一件merck millipore产品：merck millipore,默克密理博,ABE498,Anti-Lysine-specific demethylase 7 Antibody
下一件merck millipore产品：merck millipore,默克密理博,04-1017,Anti-phospho-MEK1/2 Ser218/Ser222) Antibody, clone E237, rabbit monoclonal
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