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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABE361 描述 Anti-acetyl-Histone H4 (Lys91) Antibody Alternate Names - Histone H4
背景信息 Histones are nuclear proteins that form octameric structures which bind DNA to form units of chromatin called nucleosomes. The family of histones—H2A, H2B, H3, and H4—are key players in gene regulation. They undergo a number of post-translational modifications (PTM) in response to various stimuli. Acetylation is a reversible PTM that involves the transfer of acetyl groups to N-terminal lysine (K) residues by the family of histone acetyltransferase enzymes, including GNAT, Gcn5, and p300/CBP. Histone acetylation reduces the electrostatic attractions between DNA and histones, which typically destabilizes chromatin structure and provide chromatin remodeling and transcriptional complexes with access to DNA, potentially resulting in increased gene transcription. Recent studies have suggested that acetylation of histone H4 lysine 91 facilitates the interaction of H3/H4 tetramers with H2A/H2B dimers, which is required for chromatin assembly. 产品信息 格式 Affinity Purified 控制 - Untreated and sodium butyrate treated HeLa acid extract and recombinant Histone H4
演示 Purified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-acetyl-Histone H4 is an antibody against acetyl-Histone H4 for use in WB & Dot Blot. 主要应用 - Western Blotting
应用说明 Dot Blot Analysis: A representative lot detected acetylated Histone H4 (Lys91) in an AbSurance™ Histone H2A, H2B, H4 Antibody Specificity Array (Cat. No. 16-665). 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Histone H4 acetylated at Lys91. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes Histone H4 acetylated at Lys91. 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. Expected to react with most mammals due to conserved homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_003486
基因符号 - HIST4H4
- HIST1H4A
- H4/A
- H4FA
- HIST1H4B
- H4/I
- H4FI
- HIST1H4C
- H4/G
- H4FG
- HIST1H4D
- H4/B
- H4FB
- HIST1H4E
- H4/J
- H4FJ
- HIST1H4F
- H4/C
- H4FC
- HIST1H4H
- H4/H
- H4FH
- HIST1H4I
- H4/M
- H4FM
- HIST1H4J
- H4/E
- H4FE
- HIST1H4K
- H4/D
- H4FD
- HIST1H4L
- H4/K
- H4FK
- HIST2H4A
- H4/N
- H4F2
- H4FN
- HIST2H4
- HIST2H4B
- H4/O
- H4FO
纯化方法 Affinity purified UniProt编号 - P62805
产品使用声明 质量保证 Evaluated by Western Blot in untreated and sodium butyrate treated HeLa acid extract and recombinant Histone H4.
Western Blot Analysis: A 1:2,000 dilution from a representative lot detected acetylated Histone H4 (Lys91) in 10 µg of sodium butyrate treated HeLa acid extract.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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