merck millipore,默克密理博,178276,Apicidin, Fusarium sp.

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Merck Millipore 默克密理愽

merck millipore,默克密理博,178276,Apicidin, Fusarium sp. - Calbiochem

经验配方
C₃₄H₄₉N₅O₆

描述
概述	A potent, cell-permeable inhibitor of histone deacetylase (IC₅₀= 700 pM for parasitic histone deactetylase) that also exibits antiprotozoal and potential anti-malarial properties. Inhibits HeLa cell proliferation (IC₅₀= 50-100 nM) and induces the transcriptional activation of p21 (WAF1). Also prevents H-ras-induced invasive phenotype of MCF10A cells possibly by down-regulating MMP-2.
产品目录编号	178276
品牌系列	Calbiochem®
同义词	cyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxytryptophan)-L-isoleucyl-D-pipecolinyl], HDAC Inhibitor XI

参考
参考	Colletti, S.L., et al. 2001. Bioorg. Med. Chem. Lett. 11, 107. Kim, J.S., et al. 2001. Biochem. Biophys. Res. Commun. 281, 866. Andrews, K.T., et al. 2000. Int. J. Parasitol. 30, 761. Kim, M.S., et al. 2000. Cancer Lett. 157, 23. Darkin-Rattray, S.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13143.

生物信息
主靶	Histone deacetylase
主靶IC₅₀	700 pM for parasitic histone deactetylase
纯度	≥95% by HPLC

理化信息
细胞可渗透	Y
溶解度	EtOH and DMSO

安全信息
R相	R: 26/27/28 Very toxic by inhalation, in contact with skin and if swallowed.
S相	S: 22-26-36/37/39-45 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Highly Toxic
有害材料注意事项：	Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,178276,Apicidin, Fusarium sp. - Calbiochem

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