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merck millipore,默克密理博,ABE289,Anti-trimethyl-Histone H3 (Lys18) Antibody
产品名称：Anti-trimethyl-Histone H3 (Lys18) Antibody
产品型号：ABE289
Anti-trimethyl-Histone H3 (Lys18) Antibody is a Rabbit Polyclonal Antibody for detection of trimethyl-Histone H3 (Lys18) also known as H3K18me3, Histone H3 (tri methyl K18) & has been validated in WB.
merck millipore,默克密理博,ABE289,Anti-trimethyl-Histone H3 (Lys18) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABE289 描述 Anti-trimethyl-Histone H3 (Lys18) Antibody Alternate Names - Histone H3/l
- H3K18me3
- Histone H3.1
- Histone H3/a
- Histone H3/b
- Histone H3/c
- Histone H3/d
- Histone H3/f
- Histone H3/h
- Histone H3/I
- Histone H3/j
- Histone H3/k
背景信息 Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine. 产品信息 格式 Affinity Purified 控制 - Synthetic, monomethyl-, dimethyl-, and trimethyl-Histone H3.
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-trimethyl-Histone H3 (Lys18) Antibody is a Rabbit Polyclonal Antibody for detection of trimethyl-Histone H3 (Lys18) also known as H3K18me3, Histone H3 (tri methyl K18) & has been validated in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Histone H3 trimethylated at Lys18. 表位 Trimethylated at Lys18 宿主 Rabbit 特异性 This antibody recognizes Histone H3 trimethylated at Lys18. 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with Human. Predicted to react with Mouse and Rat based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_003520
Entrez基因汇总 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. 基因符号 - H3FJ
- HIST1H3A
- H3FA
- HIST1H3B
- H3FL
- HIST1H3C
- H3FC
- HIST1H3D
- H3FB
- HIST1H3E
- H3FD
- HIST1H3F
- H3FI
- HIST1H3G
- H3FH
- HIST1H3H
- H3FK
- HIST1H3I
- H3FF
- HIST1H3J
修改 - Methylation
纯化方法 Affinity purified UniProt编号 - Q93081
UniProt汇总 FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
SUBUNIT STRUCTURE: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
SUBCELLULAR LOCATION: Nucleus. Chromosome.产品使用声明 质量保证 Evaluated by Western Blot in synthetic, monomethyl-, dimethyl-, and trimethyl-Histone H3.
Western Blot Analysis: A 1:2,000 dilution of this antibody detected trimethyl-Histone H3 in 0.5 µg of synthetic, monomethyl-, dimethyl-, and trimethyl-Histone H3.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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