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merck millipore,默克密理博,ABE223,Anti-acetyl Histone H3 (Lys4) Antibody
产品名称：Anti-acetyl Histone H3 (Lys4) Antibody
产品型号：ABE223
Use Anti-acetyl Histone H3 (Lys4) Antibody (Rabbit Polyclonal Antibody) validated in WB, IP, DB to detect acetyl Histone H3 (Lys4) also known as Histone H3.1.
merck millipore,默克密理博,ABE223,Anti-acetyl Histone H3 (Lys4) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABE223 描述 Anti-acetyl Histone H3 (Lys4) Antibody Alternate Names - h3K4Ac
- Histone H3.1
- Histone H3/a
- Histone H3/b
- Histone H3/c
- Histone H3/d
- Histone H3/f
- Histone H3/h
- Histone H3/I
- Histone H3/j
- Histone H3/k
- Histone H3/l
背景信息 Histones are nuclear proteins that form octameric structures which bind DNA to form units of chromatin called nucleosomes. The family of histones—H2A, H2B, H3, and H4—are key players in gene regulation. They undergo a number of post-translational modifications (PTM) in response to various stimuli. Acetylation is a reversible PTM that involves the transfer of acetyl groups to N-terminal lysine (K) residues by a family of histone acetyltransferase enzymes, including GNAT, Gcn5, and p300/CBP. Histone acetylation reduces the electrostatic attractions between DNA and histones, which destabilizes chromatin structure and provide chromatin remodeling and transcriptional complexes, with access to DNA, potentially resulting in increased gene transcription. In fission yeast, H3K4 is acetylated by Gcn5 and Rtt109. H3K4Ac is found at the promoters of active genes. 产品信息 格式 Affinity Purified 控制 - Sodium butyrate treated HeLa acid extract
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Use Anti-acetyl Histone H3 (Lys4) Antibody (Rabbit Polyclonal Antibody) validated in WB, IP, DB to detect acetyl Histone H3 (Lys4) also known as Histone H3.1. 主要应用 - Western Blotting
应用说明 Dot Blot Specificity Analysis: Unmodified and various modified Histone peptides (see Table) were probed with Anti-acetyl-Histone H3 (Lys4).
Immunoprecipitation Analysis: 10 μg from a representative lot immunoprecipitated acetyl Histone H3 (Lys4) from sodium butyrate treated HeLa acid extract.
Western Blotting Analysis:
Representative lot data.
Evaluated by Western Blotting in sodium butyrate treated HeLa acid extract.
Cat. No. ABE223, Anti-acetyl Histone H3 (Lys4) (1:1000 dilution). detected Histone H3 acetylated on Lys4 in 10 µg of sodium butyrate treated HeLa acid extract. Proteins were visualized using a Donkey Anti-Rabbit IgG secondary antibody conjugated to HRP and a chemiluminescence detection system.
Arrow indicates acetyl Histone H3 (Lys4) (~17 kDa).生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Histone H3 acetylated at Lys4. 表位 Acetylated Lys4 宿主 Rabbit 特异性 This antibody recognizes Histone H3 acetylated at Lys4. 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_003520
基因符号 - H3FJ
- HIST1H3A
- H3FA
- HIST1H3B
- H3FL
- HIST1H3C
- H3FC
- HIST1H3D
- H3FB
- HIST1H3E
- H3FD
- HIST1H3F
- H3FI
- HIST1H3G
- H3FH
- HIST1H3H
- H3FK
- HIST1H3I
- H3FF
- HIST1H3J
纯化方法 Affinity purified UniProt编号 - P68431
产品使用声明 质量保证 Evaluated by Western Blot in sodium butyrate treated HeLa acid extract.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected Histone H3 acetylated on Lys4 in 10 µg of sodium butyrate treated HeLa acid extract.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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