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品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 04-082 品牌系列 Upstate
商名 - Upstate
描述 Anti-BAF155/170 Antibody, clone DXD12 产品信息 格式 Purified 演示 100 μg of Protein A purified mouse monoclonal IgG in 100μl of 1X PBS, pH 7.0, 0.1% Azide. 应用 应用 This Anti-BAF155/170 Antibody, clone DXD12 is validated for use in WB for the detection of BAF155/170. 主要应用 - Western Blotting
生物信息 免疫原品种 Synthetic peptide corresponding to residues 591-608 of human BAF155. 克隆 clone DXD12 宿主 Mouse 特异性 BAF155/170 同种型 IgG 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_003074.2
Entrez基因汇总 The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. 基因符号 - Rsc8
- SMARCC1
- CRACC1
- SRG3
- BAF155
- SWI3
纯化方法 Protein A purfied UniProt编号 - Q92922
UniProt汇总 FUNCTION: SwissProt: Q92922 # Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex.
SIZE: 1105 amino acids; 122753 Da
SUBUNIT: Component of five multiprotein chromatin-remodeling complexes: Swi/Snf-A (BAF), Swi/Snf-B (PBAF), Brm, Brg1(I) and Brg1(II). Each of the five complexes contains a catalytic subunit (either SMARCA4 or SMARCA2), and at least SMARCE1, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCC2 and SMARCB1. Other subunits specific to each of the complexes may also be present. May also interact with the SIN3A histone deacetylase transcription repressor complex in conjunction with SMARCA2 and SMARCA4. The minimal complex composed of SMARCC1 and SMARCA4 seems to be able to associate with cyclin such as CCNE1 or transcription factors such as KLF1 or GATA1. Interacts with NR3C1 and SMARD1.
SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Expressed in brain, heart, muscle, placenta, lung, liver, muscle, kidney and pancreas.
PTM: Phosphorylated on undefined residues at the G2/M transition by ERK1 and other kinases. This may contribute to cell cycle specific inactivation of remodeling complexes containing the phosphorylated protein.
SIMILARITY: SwissProt: Q92922 ## Belongs to the SMARCC family. & Contains 1 SANT domain. & Contains 1 SWIRM domain.产品使用声明 质量保证 Immunoblot Analysis: A 1:1000 dilution of this antibody detected BAF155/170 in HeLa nuclear extracts. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment 包装信息 数量 100 µg
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