- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Serum Polyclonal Antibody 描述 产品目录编号 09-129 品牌系列 Upstate
商名 - Upstate
描述 Anti-SFRP4 Antibody Alternate Names - secreted frizzled-related protein 4, FRP-4, sFRP-4, FRPHE
- secreted frizzled-related protein 4
- FRP-4
- sFRP-4
产品信息 格式 Serum 应用 应用 Anti-SFRP4 Antibody detects level of SFRP4 & has been published & validated for use in WB. 主要应用 - Western Blotting
应用说明 Immunoblot: 1:500-1:5000 dilution is recommended depending on cell type and method of stimulation.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Recombinant full length human GST-tagged SFRP4 protein. 宿主 Rabbit 特异性 Recognizes SFRP4 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_003014.2
Entrez基因汇总 Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. 基因符号 - FrpHE
- SFRP4
- sFRP-4
- FRPHE
- frpHE
- MGC26498
- FRP-4
纯化方法 Serum UniProt编号 - Q6FHJ7
UniProt汇总 FUNCTION: SwissProt: Q6FHJ7 # Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.
SIZE: 346 amino acids; 39827 Da
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes.
DOMAIN:SwissProt: Q6FHJ7 The FZ domain is involved in binding with Wnt ligands (By similarity).
DISEASE:SwissProt: Q6FHJ7 # Associated with tumor-induced osteomalacia, a disorder in which there is an increase in renal phosphate excretion and a reduction in serum phosphate levels leading to hyperphosphaturia, hypophosphatemia and rickets.
SIMILARITY: Belongs to the secreted frizzled-related protein (sFRP) family. & Contains 1 FZ (frizzled) domain. & Contains 1 NTR domain.产品使用声明 质量保证 Routinely evaluated by immunoblot. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,ABC271,Anti-NOX4 Antibody
下一件merck millipore产品：merck millipore,默克密理博,401225,Goat Anti-Mouse IgM, H&L Chain Specific Peroxidase Conjugate
相关产品
merck millipore,默克密理博,MAB4383B,Anti-Nuclei Antibody, clone 3E1.3, Biotin Conjugate
merck millipore,默克密理博,MABN1023,Anti-alpha SNAP Antibody, clone EPR7372, rabbit monoclonal
merck millipore,默克密理博,194434,ABTS™ Chromophore
merck millipore,默克密理博,566325,SIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem
merck millipore,默克密理博,ABC271,Anti-NOX4 Antibody
merck millipore,默克密理博,401225,Goat Anti-Mouse IgM, H&L Chain Specific Peroxidase Conjugate
merck millipore,默克密理博,ABE223,Anti-acetyl Histone H3 (Lys4) Antibody
merck millipore,默克密理博,MAB5326A4,Anti-Nestin Antibody, clone 10C2, Alexa Fluor 488 conjugate
merck millipore,默克密理博,PEZXMSH01,Millicell EZ SLIDE Microscope Slide Holder
