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merck millipore,默克密理博,ABE1403,Anti-Cdk1/cdc2 Antibody C-term
产品名称：Anti-Cdk1/cdc2 Antibody C-term
产品型号：ABE1403
This Anti-Cdk1/cdc2 Antibody C-term is validated for use in Western Blotting and Immunohistochemistry and Immunoprecipitation for the detection of Cdk1/cdc2 C-term.
merck millipore,默克密理博,ABE1403,Anti-Cdk1/cdc2 Antibody C-term
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H, M IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABE1403 描述 Anti-Cdk1/cdc2 Antibody C-term Alternate Names - p34 protein kinase
- Cyclin-dependent kinase 1
- CDK1
- Cell division control protein 2 homolog
- Cell division protein kinase 1
背景信息 Cyclin-dependent kinase 1 (Cdk1) is also known as Cell division control protein 2 homolog (Cdc2. ;Entry of all eukaryotic cells into mitosis is regulated by activation of cdc2 kinase. Activation of cdc2 is controlled at several steps including cyclin binding and phosphorylation of Thr161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Thr14. Phosphorylation at Tyr15 and inhibition of cdc2 is carried out by Wee1 and Myt1 protein kinases, while Tyr15 dephosphorylation and activation of cdc2 is carried out by the cdc25 phosphatase. Expression of cdc2 plays a critical role in cell transition through the G2/M phase. The activity of cdc2 in dividing cells increases at the onset of M phase coincident with disassembly of the cell nucleus, generation of mitotic spindles and chromosome condensation. Several proteins including Histone H1 and pp60src are substrates for cdc2. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-Cdk1/cdc2 Antibody C-term is validated for use in Western Blotting and Immunohistochemistry and Immunoprecipitation for the detection of Cdk1/cdc2 C-term. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunoprecipitation Analysis: 2.0 µg/mL from a representative lot immunoprecipitated Cdk1/cdc2 in 500 µg of Balb/3T3/A31 cell lysate.
Immunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected Cdk1/cdc2 in human testis and human breast cancer tissue.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Cdk1/cdc2 C-term near the C-terminus. 表位 Near C-terminus 浓缩 Please refer to lot specific datasheet. 宿主 Rabbit 品种反应性 HumanMouse Species Reactivity Note Mouse, Human. Predicted to react with Rat, Hamster based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001777
基因符号 - P34CDC2
- CDK1
- CDC2
- CDC28A
- CDKN1
纯化方法 Affinity purified UniProt编号 - P06493
产品使用声明 质量保证 Evaluated by Western Blotting in Balb/3T3/A31 cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Cdk1/cdc2 in 10 µg of Balb/3T3/A31 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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