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品种反应性 主要应用 宿主 格式 抗体类型 H, R IHC, WB, ICC Rb Purified Polyclonal Antibody 描述 产品目录编号 ABC74 描述 Anti-IGPR-1 Antibody Alternate Names - IGPR-1
- Transmembrane and immunoglobulin domain-containing protein 2
- Immunoglobulin and proline-rich receptor 1
背景信息 IGPR-1 or Immunoglobulin and proline-rich receptor 1, also called Transmembrane and immunoglobulin domain-containing protein 2 and encoded by the human gene TMIGD2/IGPR1 is a widely expressed epithelial and endothelial membrane protein that plays a role in cell-cell interactions, cell migration and angiogenesis. IGPR-1 regulates cellular morphology, homophilic cell aggregation, and cell-cell interaction. IGPR-1 activity also modulates actin stress fiber formation and focal adhesion and reduces cell migration. Silencing of expression of IGPR-1 by small interfering RNA (siRNA) and by ectopic overexpression in endothelial cells showed that IGPR-1 regulates capillary tube formation in vitro, and in B16F melanoma cells engineered to express IGPR-1 displayed extensive angiogenesis in the mouse Matrigel angiogenesis model. Moreover, IGPR-1, through its proline-rich cytoplasmic domain, associates with multiple Src homology 3 (SH3)-containing signaling proteins, including SH3 protein interacting with Nck (SPIN90/WISH), bullous pemphigoid antigen-1, and calcium channel β2. 产品信息 格式 Purified 演示 Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide. 应用 应用 Anti-IGPR-1 antibody is an antibody against IGPR-1 for use in western blotting, ICC & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
- Immunocytochemistry
应用说明 Western Blotting Analysis: 2 µg/mL from a representative lot detected IGPR-1 in 10 µg of HepG2 cell lysate, human placenta tissue lysate, HUVEC cell lysate, and L9 cell lysate.
Western Blotting Analysis: A representative lot from an independent laboratory detected IGPR-1 in IGPR-1 transfected PAE cell lysates (Rahimi, N., et al. (2012). Mol Cell Biol. 23(9):1646-1556.).
Immunocytochemistry Analysis: A representative lot from an independent laboratory detected IGPR-1 in IGPR-1 transfected PAE cells (Rahimi, N., et al. (2012). Mol Cell Biol. 23(9):1646-1556.).
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected IGPR-1 in human colon cancer tissues (Rahimi, N., et al. (2012). Mol Cell Biol. 23(9):1646-1556.).生物信息 免疫原品种 Linear peptide corresponding to the cytoplasmic domain of the human mature form of IGPR-1. 表位 Cytoplasmic domain 浓缩 1 mg/mL 宿主 Rabbit 品种反应性 HumanRat 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001162597
基因符号 - IGPR1
- TMIGD2
纯化方法 Protein A purified UniProt编号 - Q96BF3
产品使用声明 质量保证 Evaluated by Western Blotting in PC-12 cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected IGPR-1 in 10 µg of PC-12 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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