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重要规格表
品种反应性 主要应用 宿主 抗体类型 R, H, M WB Rb Polyclonal Antibody 描述 产品目录编号 AB9906 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-QKI-6 Antibody Alternate Names - Quaking Protein
背景信息 QKI is an RNA-binding protein that plays a central role in myelinization. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. It is regulated by alternative splicing. 产品信息 控制 - Positive Control: Glial cells, astrocytes and oligodendrocytes.
演示 Liquid. 应用 应用 Anti-QKI-6 Antibody detects level of QKI-6 & has been published & validated for use in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Synthetic peptide from mouse QKI-6. 宿主 Rabbit 特异性 QKI-6 (Quaking Protein). The antibody recognizes the ~38 kDa protein. 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_206855.1
- NM_006775.1
- NM_206853.1
- NM_206854.1
Entrez基因汇总 QKI belongs to a family of RNA-binding proteins that have an HNRNPK (MIM 600712) homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1; MIM 602489) and SF1 (MIM 601516) (Chen and Richard, 1998 [PubMed 9671495]).[supplied by OMIM] 基因符号 - HqkI
- QKI
- DKFZp586I0923
- Hqk
- QK3
- QK
- HKQ
纯化方法 Serum UniProt编号 - Q96PU8
UniProt汇总 FUNCTION: SwissProt: Q96PU8 # RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).
SIZE: 341 amino acids; 37671 Da
SUBUNIT: Homodimer. Does not require RNA to homodimerize. Able to heterodimerize with BICC1 (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity).
TISSUE SPECIFICITY: Expressed in the frontal cortex of brain.
PTM: Methylated by PRMT1 (By similarity). & Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA (By similarity).
DISEASE: SwissProt: Q96PU8 # May play a role in genetic susceptibility to schizophrenia. QKI levels of some isoforms such as isoform 6, are frequently down-regulated in schizophrenic patients. & Deletion of the QKI gene may play a role in astrocytic tumors.
SIMILARITY: SwissProt: Q96PU8 ## Contains 1 KH domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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