merck millipore,默克密理愽
  • merck millipore,默克密理博,16-244,Anti-phospho-EGFR (Tyr1173) Antibody, clone 9H2, Alexa Fluor 488

  • merck millipore,默克密理博,16-244,Anti-phospho-EGFR (Tyr1173) Antibody, clone 9H2, Alexa Fluor 488

    产品名称：Anti-phospho-EGFR (Tyr1173) Antibody, clone 9H2, Alexa Fluor 488
    产品型号：16-244
    Anti-phospho-EGFR (Tyr1173) Antibody, clone 9H2, Alexa Fluor 488 detects level of phospho-EGFR (Tyr1173) & has been published & validated for use in FC & IC.

    merck millipore,默克密理博,16-244,Anti-phospho-EGFR (Tyr1173) Antibody, clone 9H2, Alexa Fluor 488

  • 产品介绍
  • merck millipore,默克密理博,16-244,Anti-phospho-EGFR (Tyr1173) Antibody, clone 9H2, Alexa Fluor 488

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HICC, FCMAlexaFluor®488Monoclonal Antibody
    描述
    产品目录编号 16-244
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-EGFR (Tyr1173) Antibody, clone 9H2, Alexa Fluor® 488
    产品信息
    格式 AlexaFluor®488
    应用
    应用 Anti-phospho-EGFR (Tyr1173) Antibody, clone 9H2, Alexa Fluor 488 detects level of phospho-EGFR (Tyr1173) & has been published & validated for use in FC & IC.
    主要应用
    • Immunocytochemistry
    • Flow Cytometry
    生物信息
    免疫原品种 KLH-conjugated, synthetic peptide containing the Y1173 motif (...NAE[pY1173]LRV...) of the human EGFR
    克隆 9H2
    宿主 Mouse
    特异性 the motif NAE[pY]LRV corresponding to the major autophosphorylation site of the human EGFR
    同种型 IgG1κ
    品种反应性 MouseHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_201284.1
    • NM_005228.3
    • NM_201282.1
    • NM_201283.1
    基因符号
    • mENA
    • EGFR
    • ERBB1
    • ERBB
    修改
    • Phosphorylation
    UniProt编号
    • P00533
    UniProt汇总 FUNCTION: SwissProt: P00533 # Isoform 2/truncated isoform may act as an antagonist.
    SIZE: 1210 amino acids; 134277 Da
    SUBUNIT: Binds RIPK1. CBL interacts with the autophosphorylated C- terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1.
    SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
    TISSUE SPECIFICITY: Expressed in placenta. Isoform 2 is also expressed in ovarian cancers.
    PTM: Phosphorylation of Ser-695 is partial and occurs only if Thr- 693 is phosphorylated. & Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.DISEASE:SwissProt: P00533 # Defects in EGFR are associated with lung cancer [MIM:211980].
    SIMILARITY: SwissProt: P00533 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.
    MISCELLANEOUS: Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation.
    产品使用声明
    质量保证 Routinely evaluated by positive immunostaining for phospho-EGFR in A431 cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
    储存和货运信息
    存储条件 1 year at 4°C from date of shipment
    包装信息
    数量 25 µg

    merck millipore,默克密理博,16-244,Anti-phospho-EGFR (Tyr1173) Antibody, clone 9H2, Alexa Fluor 488

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